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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Catalog Number Size Price
LS-K698-100 100 asy $655 
REN / Renin 1 Assay Kit - Inhibition of Renin Enzyme Activity with Inhibitor Aliskiren using kit protocol.

Renin Inhibitor Screening Kit (Fluorometric) - LS-K698

Renin Inhibitor Screening Kit (Fluorometric) - LS-K698

Available for shipment within the USA only
Description:
Renin (EC 3.4.23.15), also known as an angiotensinogenase, is an enzyme that participates in the renin-angiotensin system (RAS) which mediates extracellular volume (i.e. blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. An over-active renin-angiotensin system leads to vasoconstriction and retention of sodium and water, causing hypertension. Renin inhibitors are widely used for the treatment of hypertension. The Renin inhibitor screening Kit uses a synthetic peptide substrate with a fluorophore (EDANS) at one end and a quencher (DABCYL) at the other end. Renin catalyzes the cleavage of FRET substrate resulting in a product that is detected fluorometrically at Ex/Em = 328/552 nm. In the presence of a Renin inhibitor, the rate of hydrolysis of the substrate is decreased. The kit provides a rapid, simple, sensitive, and reliable test suitable for high throughput screening of Renin inhibitors also adaptable to a 384 well format.
Price
Catalog Number
$655 
LS-K698-100
100 asy

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
Renin (EC 3.4.23.15), also known as an angiotensinogenase, is an enzyme that participates in the renin-angiotensin system (RAS) which mediates extracellular volume (i.e. blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. An over-active renin-angiotensin system leads to vasoconstriction and retention of sodium and water, causing hypertension. Renin inhibitors are widely used for the treatment of hypertension. The Renin inhibitor screening Kit uses a synthetic peptide substrate with a fluorophore (EDANS) at one end and a quencher (DABCYL) at the other end. Renin catalyzes the cleavage of FRET substrate resulting in a product that is detected fluorometrically at Ex/Em = 328/552 nm. In the presence of a Renin inhibitor, the rate of hydrolysis of the substrate is decreased. The kit provides a rapid, simple, sensitive, and reliable test suitable for high throughput screening of Renin inhibitors also adaptable to a 384 well format.

Specifications

Name
Renin Inhibitor Screening Kit (Fluorometric)
Type
Inhibitor Screening
Usage
Screening potential inhibitors of renin. Characterize/study renin inhibitors
Target
REN / Renin 1
Synonyms
REN | Angiotensin-forming enzyme | Angiotensinogenase | HNFJ2 | RENAA | Renin precursor, renal | Renin
Detection
Fluorometric (Ex/Em 328/552 nm)
Components
  • Renin Assay Buffer
  • Renin Substrate
  • Active Human Renin (lyophilized 15 ug)
  • Inhibitor Control (Aliskiren 200 uM)
  • (See Datasheet for specific volumes supplied)
  • Applications
    Spectrophotometry (fluorometric)
    Equipment
    Microplate fluorometer
    Conditions
    Shipped -20°C Dry Ice, Components stored at varying temperatures. See recommended storage details in product insert, 12 months shelf life.
    Documents
    Restrictions
    For research use only. Available for shipment within the USA only
    Guarantee
    This Assay Kit carries the LSBio 100% Guarantee
    Product Features
    • Includes Inhibitor Control (Aliskiren)
    • Rapid, reliable, and simple
    • Screens potential inhibitors of Renin

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    Images

    Assay Result

    REN / Renin 1 Assay Kit - Inhibition of Renin Enzyme Activity with Inhibitor Aliskiren using kit protocol.
    Inhibition of Renin Enzyme Activity with Inhibitor Aliskiren using kit protocol.

    Assay Result

    REN / Renin 1 Assay Kit - Inhibition of Renin Enzyme Activity with Inhibitor Aliskiren using kit protocol.
    Inhibition of Renin Enzyme Activity with Inhibitor Aliskiren using kit protocol.

    Assay Result

    REN / Renin 1 Assay Kit - Inhibition of Renin Enzyme Activity with Inhibitor Aliskiren using kit protocol.
    Inhibition of Renin Enzyme Activity with Inhibitor Aliskiren using kit protocol.

    Assay Result

    REN / Renin 1 Assay Kit - Inhibition of Renin Enzyme Activity with Inhibitor Aliskiren using kit protocol.
    Inhibition of Renin Enzyme Activity with Inhibitor Aliskiren using kit protocol.

    Requested From: United States
    Date Requested: 2/23/2020