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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-K390-100 100 asy $695 
Assay Kit

Lysozyme Inhibitor Screening Kit (Fluorometric) - LS-K390

Lysozyme Inhibitor Screening Kit (Fluorometric) - LS-K390

Available for shipment within the USA only
Description:
Lysozyme (EC3.2.1.17), also known as muramidase or N-acetylmuramide glycanhydrolase, is a glycoside hydrolase. It is ubiquitously found in a wide range of biological fluids such as tears, saliva, serum, where it serves as a key effector of the innate immune system. It is also synthesized by certain carcinomas. The excessive production of lysozymes by cancer cells (especially myelomonocytic leukemia) results in higher levels of lysozyme causing renal failure. It has been demonstrated that the expression level of lysozyme is an independent prognostic factor which can be used to predict both relapse-free survival and overall survival in patients with breast carcinomas. Therefore, lysozyme inhibitors may constitute attractive, potential targets for developing anti-inflammatory and/or anti-tumor drugs. The Lysozyme Inhibitor Screening Kit uses N,N',N''-Triacetylchitotriose -a competitive inhibitor that binds to the active site of lysozyme. The inhibitor decreases the catalytic ability of lysozyme to hydrolyze a fluorogenic substrate. The kit provides a simple, rapid, sensitive and reliable test suitable for screening of lysozyme inhibitors.
Price
Catalog Number
$695 
LS-K390-100
100 asy

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
Lysozyme (EC3.2.1.17), also known as muramidase or N-acetylmuramide glycanhydrolase, is a glycoside hydrolase. It is ubiquitously found in a wide range of biological fluids such as tears, saliva, serum, where it serves as a key effector of the innate immune system. It is also synthesized by certain carcinomas. The excessive production of lysozymes by cancer cells (especially myelomonocytic leukemia) results in higher levels of lysozyme causing renal failure. It has been demonstrated that the expression level of lysozyme is an independent prognostic factor which can be used to predict both relapse-free survival and overall survival in patients with breast carcinomas. Therefore, lysozyme inhibitors may constitute attractive, potential targets for developing anti-inflammatory and/or anti-tumor drugs. The Lysozyme Inhibitor Screening Kit uses N,N',N''-Triacetylchitotriose -a competitive inhibitor that binds to the active site of lysozyme. The inhibitor decreases the catalytic ability of lysozyme to hydrolyze a fluorogenic substrate. The kit provides a simple, rapid, sensitive and reliable test suitable for screening of lysozyme inhibitors.

Specifications

Name
Lysozyme Inhibitor Screening Kit (Fluorometric)
Type
Inhibitor Screening
Usage
The kit provides a rapid, simple, sensitive, and reliable test suitable for high throughput screening of Lysozyme inhibitors. Inhibitor control (N,N',N''-Triacetylchitotriose) is included to compare the efficacy of test inhibitors.
Target
LYZ / Lysozyme
Synonyms
LYZ | 1,4-beta-N-acetylmuramidase C | LZM | Lysozyme | Lysozyme (renal amyloidosis) | Renal amyloidosis | Lysozyme C | Gal d 4 | P00698
Detection
Fluorometric (Ex/Em 360/445 nm)
Species Reactivity
Mammal
Components
  • Lysozyme Assay Buffer
  • Lysozyme substrate (in DMSO)
  • Lysozyme (lyophilized)
  • N
  • N'
  • N''-Triacetylchitotriose
  • (See Datasheet for specific volumes supplied)
  • Applications
    Spectrophotometry (fluorometric)
    Equipment
    Microplate fluorometer
    Conditions
    Shipped -20°C Dry Ice, Store at -20°C. Avoid freeze-thaw cycles, 12 months shelf life.
    Documents
    Restrictions
    For research use only. Available for shipment within the USA only
    Guarantee
    This Assay Kit carries the LSBio 100% Guarantee
    Product Features
    • Fast and convenient
    • Sensitive, stable, and high-throughput adaptable
    • Simple procedure

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    Requested From: United States
    Date Requested: 2/19/2020