SIX2

SIX homeobox 2

Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration.

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Products

Antibodies (16)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (16)

Recombinant (2)

Target

SIX2 (20)

Reactivity

Human (16)

Mouse (5)

Rat (6)

Bovine (3)

Chicken (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Pig (3)

Rabbit (3)

Sheep (3)

Xenopus (3)

Zebrafish (3)

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Application

IHC (1)

WB (16)

ELISA (8)

Host

rabbit (15)

mouse (1)

Isotype

IgG (14)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (15)

Clone

1G11 (1)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (8)

Epitope

aa89-119 (7)

aa35-84 (4)

30-110 aa, Internal (1)

Publications

No (20)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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SIX2 Antibody (30-110 aa, Internal) LS-C386068

Antibody:

SIX2 Rabbit anti-Human Polyclonal (30-110 aa, Internal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

SIX2 Antibody (aa35-84) LS-C101742

Antibody:

SIX2 Rabbit anti-Human Polyclonal (aa35-84) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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SIX2 Antibody (aa35-84, HRP) LS-C438295

Antibody:

SIX2 Rabbit anti-Human Polyclonal (aa35-84) (HRP) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

SIX2 Antibody (aa35-84, Biotin) LS-C438293

Antibody:

SIX2 Rabbit anti-Human Polyclonal (aa35-84) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SIX2 Antibody (aa35-84, FITC) LS-C438294

Antibody:

SIX2 Rabbit anti-Human Polyclonal (aa35-84) (FITC) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SIX2 Antibody (clone 1G11) LS-C139133

Antibody:

SIX2 Mouse anti-Human Monoclonal (1G11) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

SIX2 Antibody LS-C831448

Antibody:

SIX2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439

Select

SIX2 Antibody (aa89-119) LS-C325125

Antibody:

SIX2 Rabbit anti-Human Polyclonal (aa89-119) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

SIX2 Antibody (aa89-119, Biotin) LS-C240810

Antibody:

SIX2 Rabbit anti-Human Polyclonal (aa89-119) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SIX2 Antibody (aa89-119, FITC) LS-C240811

Antibody:

SIX2 Rabbit anti-Human Polyclonal (aa89-119) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SIX2 Antibody (aa89-119, APC) LS-C240809

Antibody:

SIX2 Rabbit anti-Human Polyclonal (aa89-119) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SIX2 Antibody (aa89-119, PE) LS-C240814

Antibody:

SIX2 Rabbit anti-Human Polyclonal (aa89-119) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

SIX2 Antibody (aa89-119, Azide-free, HRP) LS-C248163

Antibody:

SIX2 Rabbit anti-Human Polyclonal (aa89-119) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

SIX2 Antibody LS-C410261

Antibody:

SIX2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

SIX2 Antibody LS-C834560

Antibody:

SIX2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

SIX2 Antibody (aa89-119) LS-C158975

Antibody:

SIX2 Rabbit anti-Human Polyclonal (aa89-119) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

Human SIX2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71736

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.1 kDa

Price:

20 µg/$1,107

Select

Human SIX2 Protein (Recombinant GST) (Full Length) - LS-G32313

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

57.75 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human SIX2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90515

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.1 kDa

Price:

20 µg/$150

Select

SIX2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112481

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.1 kDa

Price:

100 µg/$494

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