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RASA2 is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants.
Gene Name: | RAS p21 protein activator 2 |
Synonyms: | RASA2, GAP1M, RASGAP, RAS p21 protein activator 2 |
Target Sequences: | NM_006506 NP_006497.2 Q15283 |
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