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ITGB2 / CD18

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.

Gene Name: integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGB2, CD18 antigen, CD18, Integrin beta chain, beta 2, LCAMB, MAC-1, MFI7, MF17, Integrin beta-2, LAD, LFA-1
Target Sequences: NM_000211 NP_000202.3 P05107

Publications (3)

1
Multiple receptors trigger human NK cell-mediated cytotoxicity against porcine chondrocytes. Sommaggio R, Cohnen A, Watzl C, Costa C. Journal of immunology (Baltimore, Md. : 1950). 2012 188:2075-83. [PubMed:22287712] Related Antibodies: LS-C40959.
2
Actinobacillus pleuropneumoniae exotoxin ApxI induces cell death via attenuation of FAK through LFA-1. Siou-Cen Li, Yu-Tsen Cheng, Ching-Yang Wang, Jia-Ying Wu, Zeng-Weng Chen, Jyh-Perng Wang, Jiunn-Horng Lin, Shih-Ling Hsuan. Scientific reports. 2021 January;11:1753. [Full Text Article] [PubMed:33462305] [PMC:PMC7813829] Related Antibodies: LS-C312785.
3
Expression of adhesion, attachment and invasion markers in eutopic and ectopic endometrium: a link to the aetiology of endometriosis. Sundqvist J, Andersson KL, Scarselli G, Gemzell-Danielsson K, Lalitkumar PG. Human reproduction (Oxford, England). 2012 Sep;27:2737-46. [Full Text Article] [PubMed:22767451] Related Antibodies: LS-B1849.

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Antibodies (193)
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ITGB2 / CD18 (218)
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ITGB2 / CD18 Antibody - Anti-ITGB2 / CD18 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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ITGB2 / CD18 Mouse anti-Human Monoclonal (MEM-48) Antibody
Human
Flo, Func, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
ITGB2 / CD18 Antibody - Anti-ITGB2 / CD18 antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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ITGB2 / CD18 Mouse anti-Human Monoclonal (aa534-546) (Low Endotoxin) (MEM-48) Antibody
Human
Flo, Func, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated, Low Endotoxin
0.05 mg/$460
ITGB2 / CD18 Antibody - ITGB2 / MAC-1 / CD18 antibody. IHC(P): Human Breast Cancer Tissue.
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ITGB2 / CD18 Rabbit anti-Human Polyclonal (aa732-748) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
ITGB2 / CD18 Antibody - Human peripheral blood lymphocytes stained with purified TS1/18, followed by anti-mouse IgGs FITC
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ITGB2 / CD18 Mouse anti-Human Monoclonal (TS1/18) Antibody
Pig, Human
Flo
Unconjugated
100 µg/$283
ITGB2 / CD18 Antibody - Immunofluorescence analysis of HeLa cells, using CD18/ITGB2 Antibody. The picture on the right is blocked with the synthesized peptide.
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ITGB2 / CD18 Rabbit anti-Human Polyclonal (aa720-769) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
ITGB2 / CD18 Protein
Select
E. coli
His-T7
27.9 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
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ITGB2 / CD18 Rat anti-Human Monoclonal (YFC118.3) Antibody
Human
Flo, IF, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$385
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ITGB2 / CD18 Rat anti-Mouse Monoclonal (M18/2) Antibody
Mouse
Flo, Func, IHC, IHC-Fr, IP, WB
Unconjugated
0.1 mg/$267
ITGB2 / CD18 Antibody - Dog peripheral blood monocytes stained with Mouse anti-Dog CD18 followed by Rabbit F(ab')2 anti-Mouse IgG:FITC
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ITGB2 / CD18 Mouse anti-Dog Monoclonal (CA1.4E9) Antibody
Dog
Flo, IF, IHC-Fr, IP
Unconjugated
0.1 mg/$402
ITGB2 / CD18 Antibody - Western blot of extracts of K562 cell lines, using ITGB2 antibody.
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ITGB2 / CD18 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
ITGB2 / CD18 Antibody - Flow cytometry of ITGB2 / MAC-1 / CD18 antibody
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ITGB2 / CD18 Mouse anti-Human Monoclonal (IB4) Antibody
Human
Flo, Func
Unconjugated
100 µg/$411
ITGB2 / CD18 Antibody - Flow cytometry of ITGB2 / MAC-1 / CD18 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ITGB2 / CD18 Mouse anti-Human Monoclonal (FITC) (IB4) Antibody
Human
Flo, Func
FITC Conjugated
120 Tests/$446
ITGB2 / CD18 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$798
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ITGB2 / CD18 Mouse anti-Human Monoclonal (Activation Epitope) (Preservative Free) (MEM-148) Antibody
Human
Flo, IP, WB
Unconjugated, Preservative Free
1 mg/$801
ITGB2 / CD18 Antibody - Western blot of lysate from HL-60 cell line, using ITGB2 Antibody. Antibody was diluted at 1:1000. A goat anti-mouse IgG H&L (HRP) at 1:3000 dilution was used as the secondary antibody. Lysate at 35ug.
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ITGB2 / CD18 Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
400 µl/$393
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ITGB2 / CD18 Rat anti-Human Monoclonal (Low Endotoxin) (YFC118.3) Antibody
Human
Flo, IF, IHC, IHC-Fr, IP
Unconjugated, Low Endotoxin
0.5 mg/$671
Select
ITGB2 / CD18 Rabbit anti-Human Polyclonal (N-Terminus) (Sepharose) Antibody
Mouse, Rat, Human
IP
Sepharose Conjugated
100 µg/$399
ITGB2 / CD18 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Select
ITGB2 / CD18 Rat anti-Human Monoclonal Antibody
Dog, Human
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$562; 200 µg/$755
Select
ITGB2 / CD18 Hamster anti-Mouse Monoclonal (12G5/2E6) Antibody
Mouse
Flo, IP
Unconjugated
500 µg/$1,320
Select
ITGB2 / CD18 Rat anti-Mouse Monoclonal (FITC) (M18/2) Antibody
Mouse
Flo
FITC Conjugated
50 µg/$270; 100 µg/$322; 500 µg/$495
ITGB2 / CD18 Antibody - Western blot analysis of CD18 expression in HEK293T (A) whole cell lysates.
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ITGB2 / CD18 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
WB
Unconjugated
100 µl/$299
ITGB2 / CD18 Antibody - IHC analysis of CD18 using anti-CD18 antibody. CD18 was detected in paraffin-embedded section of human rectal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml mouse anti-CD18 antibody overnight at 4°C. Biotinylated goat anti-mouse IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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ITGB2 / CD18 Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Select
ITGB2 / CD18 Rat anti-Mouse Monoclonal (Low Endotoxin) (M18/2) Antibody
Mouse
Flo, Func, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated, Low Endotoxin
0.1 mg/$295
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ITGB2 / CD18 Rat anti-Mouse Monoclonal (C71/16) Antibody
Mouse
Flo, IHC, IP, WB
Unconjugated
500 µg/$584
Viewing 1-25 of 218 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).