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ITGA4 / VLA-4 / CD49d
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.
| Gene Name: | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| Family/Subfamily: | Integrin , not assigned-Integrin |
| Synonyms: | ITGA4, 269C wild type, CD49D, IA4, Integrin alpha-4, Integrin alpha 4, Integrin alpha-4 subunit, Integrin alpha-IV, VLA-4, VLA-4 subunit alpha, CD49d antigen |
| Target Sequences: | NM_000885 NP_000876.3 P13612 |
Publications (6)
1
CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells. Kleinewietfeld M, Starke M, Di Mitri D, Borsellino G, Battistini L, Rtzschke O, Falk K. Blood. 2009 113:827-36.
[PubMed:18941119]
Related Antibodies: LS-C40971.
2
High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease. Palacios F, Moreno P, Morande P, Abreu C, Correa A, Porro V, Landoni AI, Gabus R, Giordano M, Dighiero G, Pritsch O, Oppezzo P. Blood. 2010 115:4488-96.
[PubMed:20233972]
Related Antibodies: LS-C40971.
3
Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells. Mattapallil MJ, Silver PB, Mattapallil JJ, Horai R, Karabekian Z, McDowell JH, Chan CC, James EA, Kwok WW, Sen HN, Nussenblatt RB, David CS, Caspi RR. Journal of immunology (Baltimore, Md. : 1950). 2011 187:1977-85.
[PubMed:21765017]
[PMC:PMC3150271]
Related Antibodies: LS-C40971.
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ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Rat, Hamster, Pig, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (9F10) Antibody
Dog, Sheep, Bovine, Cat, Horse, Human, Monkey, Baboon
Flo, IHC, IHC-Fr
Unconjugated
25 µg/$246; 100 µg/$277
ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
ITGA4 / VLA-4 / CD49d Rat anti-Mouse Monoclonal (Low Endotoxin) (PS/2) Antibody
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated, Low Endotoxin
0.5 mg/$671
ITGA4 / VLA-4 / CD49d Rat anti-Mouse Monoclonal (Azide-free, Low Endotoxin) (PS/2) Antibody
Mouse, Human
Flo, IHC, IHC-Fr, Inhb
Unconjugated, Azide-free, Low Endotoxin
0.5 mg/$409
ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Rat, Hamster, Mouse, Human
ELISA, IHC, IP, RIA, WB
Unconjugated
100 µl/$801
ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
0.1 mg/$460
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal Antibody
Bovine, Rat, Pig, Cynomolgus, Human, Monkey
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$562; 200 µg/$755
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
100 µg/$557; 200 µg/$780
ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
ITGA4 / VLA-4 / CD49d Rat anti-Mouse Monoclonal Antibody
Mouse, Human
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$562; 250 µg/$755
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (HP2/1) Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$385
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ITGA4 / VLA-4 / CD49d Rat anti-Mouse Monoclonal (PS/2) Antibody
Mouse, Human
Flo, IHC, IP
Unconjugated
0.5 mg/$380
ITGA4 / VLA-4 / CD49d Rabbit anti-Human Polyclonal (aa999-1028) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
ITGA4 / VLA-4 / CD49d Rat anti-Mouse Monoclonal (Biotin) (PS/2) Antibody
Mouse
Flo, IHC, IP
Biotin Conjugated
500 µg/$614
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (FITC) (BU49) Antibody
Human
Flo, Func, IHC
FITC Conjugated
120 Tests/$446
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (FITC) (9F10) Antibody
Cat, Cow, Horse, Dog, Sheep, Human, Non-Human Primates
Flo, Func, IHC-Fr
FITC Conjugated
100 Tests/$337
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IHC, IP, RIA
Unconjugated
100 µg/$854
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, Flo, ICC, IHC, IP, RIA, WB
PE Conjugated
100 µl/$1,149
ITGA4 / VLA-4 / CD49d Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC, IHC, IP, RIA
Unconjugated
100 µg/$820
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of 143
product results
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