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Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen.
Gene Name: | Dedicator Of Cytokinesis 5 |
Synonyms: | DOCK5, Dedicator of cytokinesis 5 |
Target Sequences: | NM_024940 NP_079216.4 Q9H7D0 |
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