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NF2 / Merlin

neurofibromin 2 (merlin)

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Gene Name: neurofibromin 2 (merlin)
Synonyms: NF2, ACN, BANF, Moesin-ezrin-radixin like, Neurofibromin 2 (merlin), Neurofibromin-2, SCH, Merlin, Schwannomerlin, Schwannomin
Target Sequences: NM_000268 NP_000259.1 P35240

☰ Filters
Antibodies (63)
Proteins (15)
ELISA Kits (5)
Cell-Based (1)
Cell-Based Phosphorylation (2)
Over-Expression Lysate (10)
Primary (63)
Recombinant (5)
Sandwich (2)
NF2 / Merlin (83)
Human (58)
Mouse (40)
Rat (26)
Bovine (4)
Chicken (6)
Dog (4)
Gibbon (3)
Guinea pig (3)
Horse (4)
Monkey (4)
Pig (4)
Rabbit (4)
Xenopus (1)
Zebrafish (5)
IHC (16)
IHC-P (6)
WB (57)
ELISA (18)
ICC (1)
IF (13)
IP (3)
Peptide-ELISA (7)
rabbit (60)
mouse (2)
goat (1)
Product Group
IHCPlus (3)
IgG (33)
IgG2b (1)
monoclonal mc (1)
polyclonal pc (62)
96-Well Microplate (3)
96-Well Strip Plate (2)
APC (2)
APC Conjugated (2)
Biotin Conjugated (4)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Preservative Free (1)
Unconjugated (43)
pSer518 (9)
aa30-239 (8)
aa30-311 (8)
aa357-406 (4)
aa550-C-term (3)
460-540 aa (2)
pSer10 (2)
1-80 aa (1)
C-Terminus (1)
Internal (1)
Thr512 (1)
aa1-50 (1)
aa363-578 (1)
aa485-534 (1)
aa506-545 (1)
aa526-536 (1)
aa65-95 (1)
p518 (1)
No (83)
Adherent Cell Cultures (3)
Plasma (1)
Serum (1)
Tissue Homogenates (2)
6His, N-terminus (1)
GST (1)
His, N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (10)
Human (9)
Mouse (1)
293T Cells (5)
E. coli (4)
HEK 293 Cells (5)
Wheat Germ Extract (1)
Purified (2)
NF2 / Merlin Antibody - Anti-NF2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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NF2 / Merlin Goat anti-Zebrafish Polyclonal (aa526-536) Antibody
Zebrafish, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
NF2 / Merlin Antibody - Anti-NF2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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NF2 / Merlin Rabbit anti-Human Polyclonal (pSer518) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
NF2 / Merlin Antibody - Merlin Antibody IHC of formalin-fixed and paraffin-embedded human lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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NF2 / Merlin Rabbit anti-Human Polyclonal (aa65-95) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
NF2 / Merlin Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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NF2 / Merlin Rabbit anti-Human Polyclonal (aa550-C-term) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
NF2 / Merlin Antibody - Western blot of Phospho-NF2 (S10) antibody
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NF2 / Merlin Rabbit anti-Human Polyclonal (1-80 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NF2 / Merlin Antibody - Immunohistochemical analysis of Merlin staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NF2 / Merlin Rabbit anti-Human Polyclonal (aa506-545) Antibody
Chicken, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
NF2 / Merlin Antibody - NF2 antibody Western blot of Fetal Brain lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NF2 / Merlin Rabbit anti-Human Polyclonal (aa357-406) (Biotin) Antibody
Chicken, Zebrafish, Pig, Horse, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon
WB
Biotin Conjugated
100 µl/$469
NF2 / Merlin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
73.7 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
NF2 / Merlin Antibody - Immunohistochemical analysis of Merlin (pS518) staining in human muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NF2 / Merlin Rabbit anti-Human Polyclonal (pSer518) Antibody
Chicken, Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$315
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NF2 / Merlin Mouse anti-Human Monoclonal (aa363-578) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$896
NF2 / Merlin Antibody - Western blot analysis of lysates from RAW264.7 cells, using Merlin Antibody. The lane on the right is blocked with the synthesized peptide.
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NF2 / Merlin Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
NF2 / Merlin Antibody - Immunohistochemistry of paraffin-embedded human brain tissue using NF2 Antibody at dilution of 1:100
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NF2 / Merlin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
NF2 / Merlin Antibody - Western blot of NF2 antibody
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NF2 / Merlin Rabbit anti-Human Polyclonal (460-540 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NF2 / Merlin Antibody - Western blot of Phospho-NF2 (S518) antibody
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NF2 / Merlin Rabbit anti-Human Polyclonal (460-540 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NF2 / Merlin Antibody - Immunofluorescence analysis of HeLa cell using NF2 antibody. Blue: DAPI for nuclear staining.
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NF2 / Merlin Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NF2 / Merlin Antibody - Detection of Human NF2 isoform 1 by Immunohistochemistry. Sample: FFPE section of human thyroid carcinoma. Antibody: Affinity purified rabbit anti-NF2 isoform 1 used at a dilution of 1:500.
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NF2 / Merlin Rabbit anti-Human Polyclonal (aa550-C-term) Antibody
Human
IF, IHC
Unconjugated
1 µg/$295; 100 µl/$532
NF2 / Merlin Antibody - Staining NIH-3T3 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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NF2 / Merlin Rabbit anti-Human Polyclonal (pSer518) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
NF2 / Merlin Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
NF2 / Merlin Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Merlin (Phospho-Ser10) antibody.
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NF2 / Merlin Rabbit anti-Human Polyclonal (pSer10) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
NF2 / Merlin Antibody - Staining NIH-3T3 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Select
NF2 / Merlin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NF2 / Merlin Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Merlin (Phospho-Ser10) Antibody. The picture on the right is blocked with the phospho peptide.
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NF2 / Merlin Rabbit anti-Human Polyclonal (pSer10) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
NF2 / Merlin Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NF2 / Merlin Antibody - Western blot of Merlin (T512) pAb in extracts from HUVEC cells.
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NF2 / Merlin Rabbit anti-Human Polyclonal (Thr512) Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
NF2 / Merlin Antibody - Immunofluorescence staining of methanol-fixed Hela cells.
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NF2 / Merlin Rabbit anti-Human Polyclonal (pSer518) Antibody
IF, WB
Unconjugated
50 µl/$341; 100 µl/$431; 200 µl/$539
NF2 / Merlin Antibody - Western blot analysis of extracts of various cell lines, using NF2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 60s.
Select
NF2 / Merlin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539
Viewing 1-25 of 83 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).