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CYP2C19

cytochrome P450, family 2, subfamily C, polypeptide 19

CYP2C19 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Gene Name: cytochrome P450, family 2, subfamily C, polypeptide 19
Family/Subfamily: Cytochrome P450 , not assigned-Cytochrome P450
Synonyms: CYP2C19, CYPIIC17, CYPIIC19, CPCJ, Cytochrome P450 2C19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase, p450C2C, p450IIC19, S-mephenytoin 4-hydroxylase, CYP2C, Cytochrome P-450 II C
Target Sequences: NM_000769 NP_000760.1 P33261

☰ Filters
Antibodies (18)
ELISA Kits (6)
Proteins (3)
Cell-Based (1)
Over-Expression Lysate (2)
Primary (18)
Recombinant (1)
Sandwich (5)
CYP2C19 (27)
Human (22)
Rat (2)
Bovine (3)
Monkey (1)
Sheep (3)
IHC (6)
IHC-P (5)
WB (15)
ELISA (3)
ICC (1)
IF (5)
Peptide-ELISA (3)
rabbit (18)
IgG (9)
polyclonal pc (18)
96-Well Microplate (2)
96-Well Strip Plate (4)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (12)
aa324-373 (4)
210-290 aa, Internal (1)
Internal (1)
Lys270 (1)
aa221-270 (1)
aa241-290 (1)
aa257-285 (1)
aa82-108 (1)
No (27)
Adherent Cell Cultures (1)
Cell Lysates (2)
Plasma (3)
Serum (3)
Tissue Homogenates (3)
Myc-DDK (Flag) (3)
Human (2)
293T Cells (1)
HEK 293 Cells (2)
CYP2C19 Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with CYP2C19 Antibody ,which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CYP2C19 Rabbit anti-Human Polyclonal (aa82-108) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CYP2C19 Antibody - Western blot of CYP2C19 antibody
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CYP2C19 Rabbit anti-Human Polyclonal (210-290 aa, Internal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CYP2C19 Antibody - Staining 293 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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CYP2C19 Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CYP2C19 Antibody - Immunohistochemical analysis of Cytochrome P450 2C19 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CYP2C19 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CYP2C19 Antibody - CYP2C19 antibody Western blot of Placenta lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP2C19 Rabbit anti-Human Polyclonal (aa324-373) Antibody
Human
WB
Unconjugated
100 µl/$424
CYP2C19 Antibody - CYP2C19 antibody Western blot of Placenta lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP2C19 Rabbit anti-Human Polyclonal (aa324-373) (HRP) Antibody
Sheep, Bovine, Human
WB
HRP Conjugated
100 µl/$469
CYP2C19 Antibody - CYP2C19 antibody Western blot of Placenta lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP2C19 Rabbit anti-Human Polyclonal (aa324-373) (Biotin) Antibody
Sheep, Bovine, Human
WB
Biotin Conjugated
100 µl/$469
CYP2C19 Antibody - CYP2C19 antibody Western blot of Placenta lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CYP2C19 Rabbit anti-Human Polyclonal (aa324-373) (FITC) Antibody
Sheep, Bovine, Human
WB
FITC Conjugated
100 µl/$469
CYP2C19 Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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CYP2C19 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
CYP2C19 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
CYP2C19 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
CYP2C19 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
CYP2C19 Antibody - IHC of CYP2C19 (K270) pAb in paraffin-embedded human liver carcinoma tissue.
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CYP2C19 Rabbit anti-Human Polyclonal (Lys270) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
CYP2C19 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CYP2C19 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
55.8 kDa
20 µg/$215
CYP2C19 Antibody - CYP2C19 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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CYP2C19 Rabbit anti-Human Polyclonal (aa257-285) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CYP2C19 Antibody - Western blot analysis of extracts from 293 cells, using Cytochrome P450 2C19 antibody.
Select
CYP2C19 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
CYP2C19 Antibody - Western blot analysis of lysates from 293 cells, using Cytochrome P450 2C19 Antibody. The lane on the right is blocked with the synthesized peptide.
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CYP2C19 Rabbit anti-Human Polyclonal (aa241-290) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CYP2C19 Antibody - Western blot analysis of the lysates from HepG2 cells using Cytochrome P450 2C19 antibody.
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CYP2C19 Rabbit anti-Human Polyclonal (aa221-270) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CYP2C19 Antibody - Western blot of 293 cell lysate using Cytochrome P450 2C19 Antibody
Select
CYP2C19 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µg/$305; 100 µg/$357
CYP2C19 Protein - Purified recombinant protein CYP2C19 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
55.8 kDa
20 µg/$1,107
CYP2C19 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
CYP2C19 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CYP2C19 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CYP2C19 ELISA Kit
Select
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
Viewing 1-25 of 27 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).