Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Monkey, Mouse, Horse, Rabbit (at least 90% immunogen sequence identity)
Protein G purified
Specificity and Use
CYP21A2 antibody was raised against synthetic peptide from human CYP21A2 / 21-Hydroxylase. Percent identity by BLAST analysis: Human, Gorilla (100%); Monkey, Mouse, Cat, Horse, Rabbit (94%); Marmoset, Panda, Bovine, Pig (88%); Rat, Hamster, Dog (82%).
KLH conjugated synthetic peptide comprising amino acids 23 - 39 [WKLRSLHLPPLAPGFLH] of the human cytochrome P450 family 21 subfamily A polypeptide 2 (CYP21A2) protein.
PBS, 0.09% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
CYP21A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia.