Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Human CRYAA / Alpha A Crystallin
Human, Mouse, Rat, Zebrafish
IHC, Immunofluorescence, Western blot
Rabbit Polyclonal (IgG) to Bovine CRYAA / Alpha A Crystallin
Bovine CRYAA / Alpha A Crystallin
Bovine (tested or 100% immunogen sequence identity)
Specificity and Use
The antibody Detects a ~20kD protein, corresponding to the apparent molecular mass of alphaA-crystallin on SDS-PAGE immunoblots, in samples from bovine. There is no reactivity with purified beta-crystallin nor alphaB-crystallin.
Western Blot (Colorimetric) 1:1000. Positive control: Bovine alphaA-Crystallin Protein.
CRYAA Antibody, Alpha-crystallin A chain Antibody, Crystallin, alpha A Antibody, CRYA1 Antibody, Crystallin, alpha-1 Antibody, Heat shock protein beta-4 Antibody, HSPB4 Antibody
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates.