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Anti-CHIT1 / Chitotriosidase Antibody LS-C35914

Catalog Size Price
LS-C35914-100 100 µg Unavailable

Most Popular CHIT1 / Chitotriosidase Antibodies

Anti-CHIT1 / Chitotriosidase Antibody LS-C35914
Mouse Monoclonal (IgG1) to Human CHIT1 / Chitotriosidase
Human, Mouse
Immunoprecipitation, ELISA, Neutralization
Anti-CHIT1 / Chitotriosidase Antibody (aa409-423) LS-C154935
Goat Polyclonal to Human CHIT1 / Chitotriosidase
Western blot, ELISA
Western blot Image
Anti-CHIT1 / Chitotriosidase Antibody LS-C341740
Rabbit Polyclonal to Human CHIT1 / Chitotriosidase
IHC, Western blot
Anti-CHIT1 / Chitotriosidase Antibody LS-C348951
Rabbit Polyclonal (IgG) to Human CHIT1 / Chitotriosidase
Human, Mouse
IHC, Western blot
Immunohistochemistry Image
Anti-CHIT1 / Chitotriosidase Antibody (aa210-464) LS-C373664
Rabbit Polyclonal (IgG) to Mouse CHIT1 / Chitotriosidase
Western blot
Western blot Image

100% Guaranteed
Mouse Monoclonal (IgG1) to Human CHIT1 / Chitotriosidase
Human, Mouse
Immunoprecipitation, ELISA, Neutralization


Human CHIT1 / Chitotriosidase
Human, Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal
Protein G purified


  • Immunoprecipitation (25 µg/ml)
  • Neutralization

Specificity and Use

NS0-derived rhCHIT-1.
Recognizes human CHIT1 in direct ELISAs and Western Blots. In these formats, this antibody shows no cross-reactivity with rhCHI-3L1. Species sequence homology: mouse: 79%.
Suitable for use in ELISA, Immunoprecipitation and Neutralization. ELISA (direct): 0.5-1.0 ug/ml. Detection limit for rhCHIT1 is approximately 2 ng/well. Immunoprecipitation: 25 ug/ml to immunoprecipitate rhCHIT1 from conditioned cell culture medium. Neutralization: The antibody was preincubated with the enzyme at different molar ratios at RT for 30 min. The enzyme was then assayed with 4-MU-beta-D-N, N', N''-triacetylchitotriose. 50% of the enzymatic activity was inhibited by the antibody at approximately 56 ng/mL (IC 50) under conditions in which the enzyme was present at 20 ng/mL and the substrate concentration was 0.01mM. IC 50 was achieved at approximately 1:1 molar ratio of the antibody to the enzyme.


100 µl deionized water
For research use only.

About CHIT1 / Chitotriosidase

Q13231 NM_003465 NP_003456.1

CHIT1 Antibody, CHITD Antibody, CHI3 Antibody, Chitinase-1 Antibody, Chitinase 1 (chitotriosidase) Antibody, Chitotriosidase Antibody, CHIT Antibody, Chitotriosidase-1 Antibody

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.

Requested From: 
Date Requested: 12/17/2017

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