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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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AXIN1 / Axin‑1 Antibody (aa898‑912) LS‑C20823 Best Seller
Antibody
Axin-1 antibody LS-C20823 is an unconjugated rabbit polyclonal antibody to Axin-1 (AXIN1) from mouse, rat and hamster. Validated for WB.
Catalog
Size
Price
LS-C20823-200
200 µg
Unavailable

Popular AXIN1 / Axin-1 Products

Antibody
Species: Human
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Product Description

Axin-1 antibody LS-C20823 is an unconjugated rabbit polyclonal antibody to Axin-1 (AXIN1) from mouse, rat and hamster. Validated for WB.
About AXIN1 / Axin-1
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. O15169 AF009674 AAC51624.1

AXIN1 Antibody, Axis inhibitor 1 Antibody, AXIN Antibody, Axin 1 Antibody, Axis inhibition protein 1 Antibody, Fused, mouse, homolog of Antibody, HAxin Antibody, PPP1R49 Antibody, Axin-1 Antibody


Specifications

Target
Mouse AXIN1 / Axin-1
Host
Rabbit
Reactivity
Mouse, Rat, Hamster (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Western blot (1 - 2 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
AXIN1 / Axin-1 antibody was raised against kLH-conjugated, synthetic peptide corresponding to amino acids 898-912 (SQRKAGGGSAPPCDS) of mouse axin. The immunizing sequence is identical in rat and has 13/15 identical amino acids in human. Percent identity by BLAST analysis: Mouse, Rat, Hamster (100%); Gibbon, Baboon, Monkey (93%); Human, Gorilla, Elephant, Dog, Bovine (87%); Marmoset, Panda, Bat (80%).
Epitope
aa898-912
Specificity
Recognizes recombinant mouse Myc-tagged Axin expressed in transfected cell lysate, Mr 130kD. Predicted to cross-react with rat and human based on sequence homology.
Usage
Western Blot: 1-2 ug/ml detects Axin in RIPA lysates from Cos-1 cells transfected with full length, mouse axin. Lysates of Cos-1 cells untransfected (lane 1) and expressing transfected Axin (lane 2) were resolved by electrophoresis, transferred to nitrocellulose and probed with anti-Axin (1 ug/ml). Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
Presentation
0.1 M Tris-glycine, pH 7.4, 0.15 M sodium chloride, 0.05% sodium azide, 30% glycerol.
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/19/2018

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