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AKT3
v-akt murine thymoma viral oncogene homolog 3
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
| Gene Name: | v-akt murine thymoma viral oncogene homolog 3 |
| Family/Subfamily: | Protein Kinase , RAC/AKT |
| Synonyms: | AKT3, AKT3/PKBgamma, PRKBG, PKB gamma, Protein kinase Akt-3, RAC-gamma, MPPH, PKB-GAMMA, PKBG, Protein kinase B gamma, RAC-PK-gamma, STK-2 |
| Target Sequences: | NM_005465 NP_005456.1 Q9Y243 |
Publications (2)
1
Akt1 mediates purinergic-dependent NOS3 activation in thick ascending limbs. Silva GB, Garvin JL. American journal of physiology. Renal physiology. 2009 297:F646-52.
[PubMed:19570880]
[PMC:PMC2739713]
Related Antibodies: LS-C96802.
2
Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells. Huang W, Gonzalez ME, Toy KA, Banerjee M, Kleer CG. Cancer research. 2010 70:3340-50.
[PubMed:20395207]
[PMC:PMC2856127]
Related Antibodies: LS-C96802.
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Low endotoxin level
(3)
AKT3 Goat anti-Human Polyclonal (aa119-133) Antibody
Chicken, Bovine, Rat, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
AKT3 Mouse anti-Human Monoclonal (aa119-136) (66C1247.1) Antibody
Chicken, Bovine, Rat, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$460
AKT3 Rabbit anti-Human Polyclonal (aa119-136) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
AKT3 Mouse anti-Human Monoclonal (Internal) (25F6.F6.D8) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$574
AKT3 Rabbit anti-Human Polyclonal (pSer472) Antibody
Human
DB
Unconjugated
400 µl/$393
AKT3 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
100 µl/$688
Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
AKT3 Mouse anti-Human Monoclonal (9H8) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
AKT3 Rabbit anti-Human Polyclonal (pSer472) (PE) Antibody
Human
DB, ELISA
PE Conjugated
200 µl/$952
Sandwich
96-Well Strip Plate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
AKT3 Rabbit anti-Human Monoclonal (154CT4.5.3) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
AKT3 Rabbit anti-Human Monoclonal (Biotin) (154CT4.5.3) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
AKT3 Rabbit anti-Human Monoclonal (FITC) (154CT4.5.3) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
AKT3 Rabbit anti-Human Monoclonal (PE) (154CT4.5.3) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
AKT3 Rabbit anti-Human Monoclonal (APC) (154CT4.5.3) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
AKT3 Rabbit anti-Human Monoclonal (Azide-free) (HRP) (154CT4.5.3) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
AKT3 Mouse anti-Human Monoclonal (OTI9B2) Antibody
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
AKT3 Mouse anti-Human Monoclonal (Carrier-free) (OTI9B2) Antibody
Mouse, Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
AKT3 Rabbit anti-Human Polyclonal (aa88-118) (PE) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC
PE Conjugated
200 µl/$952
AKT3 Mouse anti-Human Monoclonal (Internal) (Biotin) (25F6.F6.D8) Antibody
Mouse, Rat, Human
ELISA, Flo, IF, IHC, WB
Biotin Conjugated
50 µg/$562
AKT3 Mouse anti-Human Monoclonal (Internal) (RPE) (25F6.F6.D8) Antibody
Mouse, Rat, Human
ELISA, Flo, IF, IHC, WB
RPE Conjugated
50 µg/$582
AKT3 Mouse anti-Human Monoclonal (Internal) (FITC) (25F6.F6.D8) Antibody
Mouse, Rat, Human
DB, ELISA, Flo, IF, IHC, WB
FITC Conjugated
50 µg/$582
AKT3 Mouse anti-Human Monoclonal (Internal) (9A5.H9.G7) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
25 µl/$304
AKT3 Mouse anti-Human Monoclonal (Internal) (9A5.H9.G7) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
1 mg/$2,600
AKT3 Mouse anti-Human Monoclonal (Internal) (9A5.H9.G7) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µg/$574
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