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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ADRBK1 / GRK2 Antibody LS‑C11814 Best Seller
GRK2 antibody LS-C11814 is an unconjugated mouse monoclonal antibody to GRK2 (ADRBK1) from human, rat and mammal. Validated for ELISA, IF, IHC, IP and WB.
Antibody
Catalog
Size
Price
LS-C11814-100
100 µg (0.25 mg/ml)
$605

Popular ADRBK1 / GRK2 Products

Western blot of ADRBK1 (arrow) using rabbit polyclonal ADRBK1 Antibody (N-term) LS-C97473. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ADRBK1 gene (Lane 2).
Species: Human
Applications: Western blot
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with GRK2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA
Immunohistochemical analysis of GRK2 (pS29) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Species: Human, Mouse, Rat, Bovine
Applications: IHC, IHC - Paraffin, Western blot

Product Description

GRK2 antibody LS-C11814 is an unconjugated mouse monoclonal antibody to GRK2 (ADRBK1) from human, rat and mammal. Validated for ELISA, IF, IHC, IP and WB.
About ADRBK1 / GRK2
Beta-adrenergic receptor kinase (ADRBK1) phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. The ADRBK1 gene spans approximately 23 kb and is composed of 21 exons. P25098 NM_001619 NP_001610.2

ADRBK1 Antibody, BARK1 Antibody, Beta-ARK-1 Antibody, BETA-ARK1 Antibody, BARK Antibody, Betaark1 Antibody, GRK2 Antibody


Specifications

Target
Human ADRBK1 / GRK2
Host
Mouse
Reactivity
Human, Rat, Mammal (tested or 100% immunogen sequence identity)
Clonality
IgG2b Monoclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein A purified
Modifications
Unmodified
Applications
  • IHC (10 µg/ml)
  • Immunofluorescence (3 - 10 µg/ml)
  • Western blot (1 - 5 µg/ml)
  • Immunoprecipitation
  • ELISA (0.1 - 1 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
ADRBK1 / GRK2 antibody was raised against full length recombinant b-adrenergic receptor kinase.
Specificity
Reacts with mammalian b-adrenergic receptor kinase. Species cross-reactivity: Human and rat.
Usage
Suitable for use in Immunofluorescence, ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Immunofluorescence: 3-10 ug/ml. ELISA: 0.1-1 ug/ml. Western Blot: 1-5 ug/ml. Immunohistochemistry: 10 ug/ml. Immunoprecipitation: 10 ug/IP reaction.
Presentation
PBS, pH 7.4, 0.1% Sodium Azide, 40% Glycerol
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/16/2018

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