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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ADAP / FYB Antibody (aa755‑768) LS‑C3555 Best Seller
FYB antibody LS-C3555 is an unconjugated rabbit polyclonal antibody to FYB (ADAP) from human, mouse, rat and other species. Validated for IP and WB.
Antibody
Catalog
Size
Price
LS-C3555-200
200 µg (1 mg/ml)
$650

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Product Description

FYB antibody LS-C3555 is an unconjugated rabbit polyclonal antibody to FYB (ADAP) from human, mouse, rat and other species. Validated for IP and WB.
About ADAP / FYB
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. O15117 NM_001465 NP_001456.3

FYB Antibody, ADAP Antibody, FYN-binding protein Antibody, FYN-T-binding protein Antibody, FYB-120/130 Antibody, FYN binding protein Antibody, p120/p130 Antibody, PRO0823 Antibody, SLAP130 Antibody, SLAP-130 Antibody


Specifications

Target
Mouse ADAP / FYB
Host
Rabbit
Reactivity
Mouse, Human, Monkey, Rat, Bat, Bovine, Dog, Horse, Pig (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein A purified
Modifications
Unmodified
Applications
  • Western blot (0.5 - 2 µg/ml)
  • Immunoprecipitation
  • (applications tested for the base form of this product only)
Failed Applications
  • IHC - Paraffin
Immunogen
ADAP / FYB antibody was raised against synthetic peptide corresponding to amino acids 755-768 (DNDGEIYDDIADGC) of mouse Fyn binding protein (ADAP/SLAP-130/Fyb) (KLH). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Mouse, Rat, Bovine, Dog, Bat, Horse, Pig (100%); Platypus (93%).
Epitope
aa755-768
Specificity
Recognizes ADAP/SLAP-130/Fyb, Mr ~130kD. An unknown protein was also detected, Mr ~40kD that is also inhibited by the immunizing peptide. Species sequence homology: Human and rat.
Usage
Suitable for use in Western Blot and Immunoprecipitation. Proteins were visualized using an IgG (HRP) goat anti-rabbit and a chemiluminescence detection system. Immunoprecipitation: 4 ug immunoprecipitated ADAP/SLAP-130/Fyb from 500 ug of RAW. 264.7 macrophage RIPA lysate.
Presentation
0.1 M Tris-Glycine, pH 7.4, 0.15 M NaCl, 0.05% Sodium Azide, 30% Glycerol
Storage
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/16/2018

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