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Anti-ABCB1 / MDR1 / P Glycoprotein Antibody (clone JSB-1) LS-C11667

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Mouse Monoclonal [clone JSB-1] (IgG1) to Human ABCB1 / MDR1 / P Glycoprotein
Human
IHC - Paraffin, IHC - Frozen, Flow Cytometry
Unconjugated

Details

Human ABCB1 / MDR1 / P Glycoprotein
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [JSB-1]
Tissue culture supernatant

Applications

IHC - Paraffin (1:10 - 1:20), IHC - Frozen (1:10 - 1:20), Flow Cytometry

Specificity and Use

ABCB1 / MDR1 / P Glycoprotein antibody was raised against multi drug resistant Chinese hamster ovary cell line, CHrC5.
Recognizes the 170-180kD P-glycoprotein, a plasma membrane associated molecule which is important in mediating resistance to cytotoxic drugs. In normal tissues P-glycoprotein is expressed in liver, kidney, colon, adrenal gland and lung. In malignant conditions increased expression of P-glycoprotein may be associated with multi-drug resistance, and the detection of this can have important consequences for treatment. This clone has also been reported to be suitable for Western blot analysis.
Immunohistology: This product requires protein digestion pre-treatment of paraffin sections e. g. 0.1% pronase, 10 mins.

Packaging

PBS, 0.09% sodium azide, 1% BSA.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About ABCB1 / MDR1 / P Glycoprotein

P08183 NM_000927 NP_000918.2

ABCB1 Antibody, ABC20 Antibody, Abcb1b Antibody, CLCS Antibody, Colchicin sensitivity Antibody, CD243 Antibody, Doxorubicin resistance Antibody, IBD13 Antibody, gp170 Antibody, MDR1 Antibody, Multidrug resistance protein 1 Antibody, P glycoprotein Antibody, P-glycoprotein 1 Antibody, P-GP Antibody, CD243 antigen Antibody, PGY1 Antibody

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance.

Requested From: United States
Date Requested: 9/28/2016

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