Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibodies
Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1)
|
Target Details
|
ABL1, an Abl type protein kinase, is associated with cell differentiation, cell division, cell adhesion and stress response. Kinase activity of nuclear ABL1 is mediated by retinoblastoma protein. Additionally, ABL1 has been shown to bind nuclear DNA, and this binding activity is regulated by CDC2-mediated phosphorylation. ABL1 (-/-) mice are osteoporotic and display increased perinatal mortality, reduced fertility, foreshortened crania and defects in the maturation of B cells in bone marrow. At least two mRNA isoforms have been reported, 6- or 7-kb, with alternatively spliced first exons joined to the common exons 2-11. Alterations of ABL1 by chromosomal rearrangement or viral transduction lead to malignant transformation. Further, a very long intron in the ABL1 gene is a target for translocations. Translocations of ABL1 to the breakpoint cluster region (BCR) on chromosome 22 lead to chronic myeloid leukemia and acute lymphocytic leukemia.
| Featured Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody |
 |
|
LS-B1166
is a rabbit polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue.
|
| (More) |
Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibodies (38)
| Target | Catalog | Type | Form | Epitope | Assay | Reactivity | Size | Price | Buy |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-B1166 | Rabbit IgG | | Tyr412 | IHC-P | Human, Mouse | 50 µg | $350 |  |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-B2776 | Mouse IgG1 | | | IHC-P, WB, IP, IF | Human, Mouse | 50 µg | $350 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C33822 | Mouse IgG1 | | | IHC, WB, IP, IF, ELISA | Mouse, Human | 50 µg | $295 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C88554 | Mouse IgG1 | | SH2 Domain | IHC-P, WB, IP, IF | Human, Mouse | 20 µg | $250 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C33821 | Rabbit | | | IHC, WB, IP, ELISA | Human, Mouse | 50 µg | $295 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C88555 | Mouse IgG1 | Biotin | | IHC-P, WB, IP, IF | Human, Mouse | 20 µg | $280 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C99160 | Rabbit | | C-Terminus | IHC-P, WB, ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C99162 | Rabbit | | Internal | IHC-P, WB, ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C97401 | Rabbit | | pTyr251 | IHC-P, WB, ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C97399 | Rabbit | | pTyr134 | IHC-P, WB, ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C97400 | Rabbit | | pTyr245 | IHC-P, WB, ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C97403 | Rabbit | | pTyr276 | IHC-P, ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C97402 | Rabbit | | pTyr272 | IHC-P, ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C97398 | Rabbit | | pSer588 | IHC, ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C51272 | Rabbit IgG | | pTyr412 | IHC | Human, Mouse | 40 µg | $245 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C77356 | Rabbit IgG | | | IHC-P, WB, IP | Human, Mouse | 500 µl | $470 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C20984 | Rabbit IgG | | C-Terminus | IHC, ICC, IP | Human | 100 µl | $445 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C77351 | Rabbit IgG | | | IHC-P | Human, Mouse | 7000 µl | $480 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C109117 | Mouse IgG1 | | | WB, ELISA | Human | 100 µl | $320 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C49588 | Rabbit IgG | | | WB, IP | Human, Rat | 100 µl | $350 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C53735 | Rabbit | | pTyr412 | WB | Human, Mouse | 10 blot | $488 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C53734 | Rabbit | | pTyr245 | WB | Human, Mouse | 10 blot | $488 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C45601 | Mouse IgG1 | | | WB, IP, IF | Human, Mouse | 100 µg | $365 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C99161 | Rabbit | | N-Terminus | WB, ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C99159 | Rabbit | | N-Terminus | WB, ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C96836 | Rabbit | | pThr754 | ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C96835 | Rabbit | | pTyr283 | ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C96814 | Rabbit | | pTyr204 | ELISA | Human | 100 µg | $267 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C12199 | Rabbit IgG | | C-Terminus | WB, IP, IF, ELISA | Human, Mouse, Rat | 100 µl | $405 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C12193 | Rabbit IgG | | N-Terminus | ICC, WB, Flo, ELISA | Human, Mouse, Rat | 100 µl | $405 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C20250 | Rabbit IgG | | aa929-1020 | WB, IP | Mouse, Human | 250 µg | $485 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C34784 | Rabbit IgG | | | WB, Func | | 200 µg | $485 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C12200 | Rabbit IgG | | pTyr245 | WB, ELISA | Human, Mouse | 100 µl | $440 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C20249 | Rabbit IgG | | | WB, IP | Mouse, Human | 250 µg | $485 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C77349 | Mouse IgG2a | | | WB | Human, Mouse, Rat | 100 µl | $450 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C77354 | Rabbit IgG | | pTyr412 | WB | Human | 100 µl | $480 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C12201 | Rabbit | | pTyr245 | WB | Human | 100 µl | $500 | |
| Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Antibody | LS-C12202 | Rabbit IgG | | pThr735 | WB | Human | 100 µl | $430 | |
Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) Target Details
| Gene Name: |
Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1) |
| Family/Subfamily: |
Protein Kinase, Abl |
| Synonyms: |
ABL1, Abl, Bcr-Abl, c-abl, jtk7, p150, proto-oncogene tyrosine-protein kinase abl, v-abl, v-abl abelson murine leukemia viral oncogene homolog 1 |
| Target Sequences: |
NM_005157
NP_005148.2
P00519 |
| Features: |
| Feature Type | Location | Details |
| Disease | 1 - 1130 | A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). |
| Function | 1 - 1130 | Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. |
| Modification | 50 - 50 | Phosphoserine |
| Modification | 185 - 185 | Phosphotyrosine |
| Modification | 226 - 226 | Phosphotyrosine; by autocatalysis |
| Modification | 253 - 253 | Phosphotyrosine |
| Modification | 257 - 257 | Phosphotyrosine |
| Modification | 264 - 264 | Phosphotyrosine |
| Modification | 393 - 393 | Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases. |
| Modification | 394 - 394 | Phosphothreonine |
| Modification | 446 - 446 | Phosphoserine (By similarity) |
| Modification | 469 - 469 | Phosphotyrosine |
| Modification | 569 - 569 | Phosphoserine |
| Modification | 613 - 613 | Phosphothreonine |
| Modification | 620 - 620 | Phosphoserine |
| Modification | 659 - 659 | Phosphoserine |
| Modification | 683 - 683 | Phosphoserine |
| Modification | 718 - 718 | Phosphoserine |
| Modification | 735 - 735 | Phosphothreonine |
| Modification | 781 - 781 | Phosphothreonine |
| Modification | 805 - 805 | Phosphoserine |
| Modification | 809 - 809 | Phosphoserine |
| Modification | 814 - 814 | Phosphothreonine |
| Modification | 844 - 844 | Phosphothreonine |
| Modification | 852 - 852 | Phosphothreonine |
| Modification | 917 - 917 | Phosphoserine |
| Modification | 919 - 919 | Phosphoserine |
| Modification | 936 - 936 | Phosphoserine |
| Modification | 949 - 949 | Phosphoserine |
| Modification | 977 - 977 | Phosphoserine |
| Molecular Weight | 1 - 1130 | 122873 |
| Similarity | 1 - 1130 | Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. |
| Similarity | 1 - 1130 | Contains 1 protein kinase domain. |
| Similarity | 1 - 1130 | Contains 1 SH2 domain. |
| Similarity | 1 - 1130 | Contains 1 SH3 domain. |
| Subcellular Location | 1 - 1130 | Cytoplasm, cytoskeleton. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. |
| Subunit | 1 - 1130 | Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16 (By similarity). Interacts with INPPL1/SHIP2. Interacts with the 14-3- 3 proteins, YWHAB, YWHAE, YWHAG, YWHAH, SFN AND YWHAZ; the interaction with 14-3-3 proteins requires phosphorylation on Thr- 735 and, sequesters ABL1 into the cytoplasm. |
| Tissue Specificity | 1 - 1130 | Widely expressed. |
|
If you do not find the reagent or information you require, please contact
customer.support@lsbio.com to inquire about
additional products in development.
|