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WT5 / POU6F2 is a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene Name: | POU class 6 homeobox 2 |
Synonyms: | POU6F2, POU class 6 homeobox 2, WTSL, Wilms tumor suppressor locus, RPF-1, WT5 |
Target Sequences: | NM_007252 NP_009183.3 P78424 |
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