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SQSTM1
sequestosome 1
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.
| Gene Name: | sequestosome 1 |
| Synonyms: | SQSTM1, A170, ORCA, OSIL, Paget disease of bone 3, p60, p62, PDB3, Sequestosome-1, Ubiquitin-binding protein p62, Oxidative stress induced like, p62B, ZIP3, Sequestosome 1, EBI3-associated protein p60, EBIAP |
| Target Sequences: | NM_003900 NP_003891.1 Q13501 |
Publications (5)
1
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease. Ju JS, Miller SE, Hanson PI, Weihl CC. The Journal of biological chemistry. 2008 283:30289-99.
[PubMed:18715868]
[PMC:PMC2573070]
Related Antibodies: LS-C161484.
2
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Nascimento-Ferreira I, Santos-Ferreira T, Sousa-Ferreira L, Auregan G, Onofre I, Alves S, Dufour N, Colomer Gould VF, Koeppen A, Dglon N, Pereira de Almeida L. Brain : a journal of neurology. 2011 134:1400-15.
[PubMed:21478185]
Related Antibodies: LS-C161484.
3
Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. Hubbs AF, Fluharty KL, Edwards RJ, Barnabei JL, Grantham JT, Palmer SM, Kelly F, Sargent LM, Reynolds SH, Mercer RR, Goravanahally MP, Kashon ML, Honaker JC, Jackson MC, Cumpston AM, Goldsmith WT, McKinney W, Fedan JS, Battelli LA, Munro T, Bucklew-Moyers W, McKinstry K, Schwegler-Berry D, Friend S, Knepp AK, Smith SL, Sriram K. The American journal of pathology. 2016 186:2887-2908. (IF; Mouse)
[Full Text Article]
[PubMed:27643531]
[PMC:PMC5222965]
Related Antibodies: LS-B4617.
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SQSTM1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
SQSTM1 Rabbit anti-Human Polyclonal (aa91-110) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SQSTM1 Rabbit anti-Human Polyclonal (aa323-372) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SQSTM1 Guinea pig anti-Human Polyclonal (aa421-440) Antibody
Rabbit, Mouse, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µl/$993
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
SQSTM1 Rabbit anti-Human Polyclonal (aa317-346) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SQSTM1 Mouse anti-Human Monoclonal (OTI4E2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
SQSTM1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC-P, WB
Unconjugated
0.1 ml/$460
SQSTM1 Mouse anti-Human Monoclonal (OTI1E9) Antibody
Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SQSTM1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1E9) Antibody
Rat, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SQSTM1 Mouse anti-Human Monoclonal (OTI5A1) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SQSTM1 Rabbit anti-Human Polyclonal (pSer207) Antibody
Human
DB
Unconjugated
400 µl/$393
SQSTM1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$553
SQSTM1 Rabbit anti-Human Polyclonal (aa325-375) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SQSTM1 Rabbit anti-Human Polyclonal (aa317-346) (Biotin) Antibody
Human
ELISA, IF, IHC, WB
Biotin Conjugated
200 µl/$952
SQSTM1 Rabbit anti-Human Polyclonal (aa300-360) Antibody
Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µg/$393
SQSTM1 Rabbit anti-Human Polyclonal (aa425-440) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
SQSTM1 Mouse anti-Human Monoclonal (1C9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
SQSTM1 Mouse anti-Human Monoclonal (OTI4A12) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SQSTM1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4A12) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SQSTM1 Mouse anti-Human Monoclonal (OTI5A2) Antibody
Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
SQSTM1 Mouse anti-Human Monoclonal (Carrier-free) (OTI5A2) Antibody
Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SQSTM1 Mouse anti-Human Monoclonal (Carrier-free) (UMAB12) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$539
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