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SNAI2 / SLUG

snail family zinc finger 2

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

Gene Name:	snail family zinc finger 2
Family/Subfamily:	Zinc Finger
Synonyms:	SNAI2, SLUG, SLUGH1, Snail homolog 2 (Drosophila), SNAIL2, SLUGH, Protein snail homolog 2, WS2D, Zinc finger protein SNAI2
Target Sequences:	NM_003068 NP_003059.1 O43623

Publications (12)

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA. Genes & development. 2006 20:3130-46. [PubMed:17114584] [PMC:PMC1635148]

Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium. Kato N, Shimmura S, Kawakita T, Miyashita H, Ogawa Y, Yoshida S, Higa K, Okano H, Tsubota K. Investigative ophthalmology & visual science. 2007 48:1511-7. [PubMed:17389479]

Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype. Belguise K, Guo S, Yang S, Rogers AE, Seldin DC, Sherr DH, Sonenshein GE. Cancer research. 2007 67:11742-50. [PubMed:18089804]

Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha. Park SH, Cheung LW, Wong AS, Leung PC. Molecular endocrinology (Baltimore, Md.). 2008 22:2085-98. [PubMed:18550773]

Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. Fu J, Lv X, Lin H, Wu L, Wang R, Zhou Z, Zhang B, Wang YL, Tsang BK, Zhu C, Wang H. The Journal of biological chemistry. 2010 285:10870-9. [PubMed:20139075] [PMC:PMC2856293]

The postnatal accumulation of junctional E-cadherin is inversely correlated with the capacity for supporting cells to convert directly into sensory hair cells in mammalian balance organs. Collado MS, Thiede BR, Baker W, Askew C, Igbani LM, Corwin JT. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:11855-66. [PubMed:21849546] [PMC:PMC3164812]

Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C179060.

Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis. Ruffenach G, Umar S, Vaillancourt M, Hong J, Cao N, Sarji S, Moazeni S, Cunningham CM, Ardehali A, Reddy ST, Saggar R, Fishbein G, Eghbali M. EMBO molecular medicine. 2019 September;11:e10061. [Full Text Article] [PubMed:31468711] [PMC:PMC6728601] Related Antibodies: LS-C175161.

Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomas. Niu DF, Kondo T, Nakazawa T, Oishi N, Kawasaki T, Mochizuki K, Yamane T, Katoh R. Laboratory investigation; a journal of technical methods and pathology. 2012 Aug;92:1181-90. [Full Text Article] [PubMed:22641097] Related Antibodies: LS-B554.

An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer. Katz E, Dubois-Marshall S, Sims AH, Gautier P, Caldwell H, Meehan RR, Harrison DJ. PloS one. 2011 6:e17083. [Full Text Article] [PubMed:21347235] [PMC:PMC3039655] Related Antibodies: LS-B5598.

The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma. O'Mahony FC, Faratian D, Varley J, Nanda J, Theodoulou M, Riddick AC, Harrison DJ, Stewart GD. PloS one. 2012 7:e31557. [Full Text Article] [PubMed:22363672] [PMC:PMC3283650] Related Antibodies: LS-B5598.

Two possible mechanisms of epithelial to mesenchymal transition in invasive ductal breast cancer. Dubois-Marshall S, Thomas JS, Faratian D, Harrison DJ, Katz E. Clinical & experimental metastasis. 2011 Dec;28:811-8. [Full Text Article] [PubMed:21789718] Related Antibodies: LS-B5598.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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