SMARCA2 / BRM

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

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Products

Proteins (3)

Type

Recombinant (3)

Target

SMARCA2 / BRM (3)

Publications

No (3)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His-SUMO (1)

Species

Human (3)

Source

E. coli (1)

Wheat Germ Extract (1)

Yeast (1)

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Human SMARCA2 / BRM Protein (Recombinant 6His, N-terminus) (aa700-1216) - LS-G23136

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

61.7 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human SMARCA2 / BRM Protein (Recombinant His-SUMO) (aa700-1216) - LS-G21196

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

75.7 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SMARCA2 / BRM Protein (Recombinant GST, N-terminus) (aa659-735) - LS-G60138

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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