SMAD3

SMAD family member 3

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

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Products

Proteins (17)

Type

Over-Expression Lysate (4)

Recombinant (13)

Target

SMAD3 (17)

Publications

No (17)

Tag

10His, N-terminus (1)

6His, N-terminus (1)

6His-DDK (Flag), C-terminus (1)

GST (1)

GST, N-terminus (3)

His (3)

His-GST (1)

His-SUMO (1)

Myc-DDK (Flag) (5)

Species

Human (13)

Mouse (2)

Source

293T Cells (2)

Baculovirus (2)

E. coli (6)

HEK 293 Cells (3)

Wheat Germ Extract (4)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

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Human SMAD3 Protein (Recombinant 6His, N-terminus) (Ser2-Ser425) - LS-G51858

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

50.3kD

Price:

10 µg/$277; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627

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Human SMAD3 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G59160

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human SMAD3 Protein (Recombinant GST, N-terminus) (aa147-270) - LS-G59163

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SMAD3 Protein (Recombinant GST, N-terminus) (aa120-221) - LS-G59162

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SMAD3 Protein (Recombinant His-SUMO) (Full Length) - LS-G21195

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

64 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SMAD3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68246

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.9 kDa

Price:

20 µg/$1,107

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Human SMAD3 Protein (Recombinant 10His, N-terminus) (Full Length) - LS-G136854

Source:

Baculovirus

Tag:

10His, N-terminus

Molecular Weight:

50.6 kDa

Price:

100 µg/$810; 20 µg/$387; 1 mg/$1,678

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Mouse SMAD3 Protein (Recombinant His-GST) (Met1-Ser425) - LS-G98281

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

75.9 kDa

Price:

100 µg/$511

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Human SMAD3 Protein (Recombinant His) (aa231-425) - LS-G14796

Source:

E. coli

Tag:

His

Molecular Weight:

23.5 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Mouse SMAD3 Protein (Recombinant His) (aa231-425) - LS-G14798

Source:

E. coli

Tag:

His

Molecular Weight:

23.5 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human SMAD3 Protein (Recombinant His) - LS-G650

Source:

E. coli

Tag:

His

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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Human SMAD3 Protein (Recombinant GST) (Full Length) - LS-G29240

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

37.95 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SMAD3 Protein (Recombinant 6His-DDK (Flag), C-terminus) (Ser2-Ser425) - LS-G139117

Source:

E. coli

Tag:

6His-DDK (Flag), C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

50.3 kDa

Price:

10 µg/$277; 50 µg/$389

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Human SMAD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81738

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.1 kDa

Price:

20 µg/$150

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Human SMAD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81740

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.9 kDa

Price:

20 µg/$150

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SMAD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100669

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.9 kDa

Price:

100 µg/$494

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SMAD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126523

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.1 kDa

Price:

100 µg/$494

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