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SCN4A / Nav1.4

sodium channel, voltage-gated, type IV, alpha subunit

Scn4a encodes the alpha subunit of the type IV voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone can generate a functional channel in vitro >, but it's kinetic properties are modulated by beta subunits. The type IV channel is tetrodotoxin-sensitive. Mutations in the Scn4a gene have been shown to be responsible for hyperkalemic periodic paralysis, paramyotonia congenita and some forms of malignant hyperthermia.

Gene Name: sodium channel, voltage-gated, type IV, alpha subunit
Family/Subfamily: Ion Channel , Sodium channel - voltage-gated
Synonyms: SCN4A, HOKPP2, Mu1, NAC1A, Na(V)1.4, NCHVS, HSkM1, RSkM1, MH2, MicroI, SkM1, HYKPP, HYPP, Nav1.4
Target Sequences: NM_000334 NP_000325.4 P35499

☰ Filters
Antibodies (8)
Proteins (2)
Over-Expression Lysate (2)
Primary (8)
SCN4A / Nav1.4 (10)
Human (8)
Mouse (8)
Rat (8)
IHC (1)
WB (8)
ELISA (2)
IF (1)
Peptide-ELISA (3)
rabbit (8)
IgG (5)
polyclonal pc (8)
Unconjugated (8)
400-480 aa, Internal (1)
Internal (1)
aa413-462 (1)
aa431-480 (1)
aa472-517 (1)
No (10)
Myc-DDK (Flag) (2)
Human (1)
293T Cells (1)
HEK 293 Cells (1)
SCN4A / Nav1.4 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Select
SCN4A / Nav1.4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
SCN4A / Nav1.4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
200 µl/$468
SCN4A / Nav1.4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
207.9 kDa
100 µg/$710
SCN4A / Nav1.4 Antibody - Western blot analysis of the lysates from COLO205 cells using SCN4A antibody.
Select
SCN4A / Nav1.4 Rabbit anti-Human Polyclonal (aa413-462) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
SCN4A / Nav1.4 Rabbit anti-Human Polyclonal (400-480 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
SCN4A / Nav1.4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Select
SCN4A / Nav1.4 Rabbit anti-Human Polyclonal (aa431-480) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
SCN4A / Nav1.4 Rabbit anti-Human Polyclonal (aa472-517) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
SCN4A / Nav1.4 Antibody - Western blot analysis of Nav1.4 expression in MCF7 (A); NIH3T3 (B); H9C2 (C); mouse brain (D) whole cell lysates.
Select
SCN4A / Nav1.4 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
SCN4A / Nav1.4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
207.9 kDa
20 µg/$215
Viewing 1-10 of 10 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).