PRKACA

protein kinase, cAMP-dependent, catalytic, alpha

Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca2+, leading to reduced amplitude and increased frequency of store overload-induced Ca2+ release (SOICR) characterized by an increased rate of Ca2+ release and propagation velocity of spontaneous Ca2+ waves, despite reduced wave amplitude and resting cytosolic Ca2+. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation.

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Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

PRKACA (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (2)

Myc-DDK (Flag) (6)

Species

Human (7)

Source

293T Cells (2)

HEK 293 Cells (4)

Wheat Germ Extract (3)

Purification

Purified (1)

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Human PRKACA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65161

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.4 kDa

Price:

20 µg/$1,107

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Human PRKACA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65162

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.6 kDa

Price:

20 µg/$1,107

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Human PRKACA Protein (Recombinant GST, N-terminus) (aa1-120) - LS-G59716

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PRKACA Protein (Recombinant GST, N-terminus) (aa252-350) - LS-G59718

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PRKACA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74972

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.4 kDa

Price:

20 µg/$150

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Human PRKACA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74973

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.6 kDa

Price:

20 µg/$150

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PRKACA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102710

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.6 kDa

Price:

100 µg/$494

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PRKACA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117794

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.4 kDa

Price:

100 µg/$494

Select

Human PRKACA Protein (Recombinant GST) (Full Length) - LS-G29893

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

64.35 kDa

Price:

10 µg/$479; 25 µg/$670

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