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PKP2 / Plakophilin 2

plakophilin 2

PKP2 / Plakophilin 2 is a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.

Gene Name: plakophilin 2
Synonyms: PKP2, ARVD9, Plakophilin 2, Plakophilin-2
Target Sequences: NM_004572 NP_004563.2 Q99959

Publications (1)

1
Progressive cardiac arrhythmias and ECG abnormalities in the Huntington's disease BACHD mouse model. Yujie Zhu, Isaac Shamblin, Efrain Rodriguez, Grace E Salzer, Lita Araysi, Katherine A Margolies, Ganesh V Halade, Silvio H Litovsky, Steven Pogwizd, Michelle Gray, Sabine Huke. Human molecular genetics. 2020 February;29:369-381. [Full Text Article] [PubMed:31816043] [PMC:PMC7015842] Related Antibodies: LS-B9231.

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Proteins (3)
Over-Expression Lysate (2)
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PKP2 / Plakophilin 2 (3)
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His-T7 (1)
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E. coli (1)
HEK 293 Cells (1)
PKP2 / Plakophilin 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
92.6 kDa
20 µg/$150
PKP2 / Plakophilin 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
92.6 kDa
100 µg/$494
PKP2 / Plakophilin 2 Protein - Recombinant Plakophilin 2 By SDS-PAGE
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E. coli
His-T7
34.7 kDa
50 µg/$470; 10 µg/$285; 200 µg/$937; 100 µg/$750; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).