PKN2

protein kinase N2

PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.

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Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

PKN2 (7)

Publications

No (7)

Tag

GST, N-terminus (1)

His (3)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human PKN2 Protein (Recombinant GST, N-terminus) (aa580-679) - LS-G59734

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PKN2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66641

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

111.9 kDa

Price:

20 µg/$1,107

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Mouse PKN2 Protein (Recombinant His) (aa282-487) - LS-G14581

Source:

E. coli

Tag:

His

Molecular Weight:

24.8 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human PKN2 Protein (Recombinant His) (aa67-312) - LS-G14576

Source:

E. coli

Tag:

His

Molecular Weight:

29.5 kDa

Price:

10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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Human PKN2 Protein (Recombinant His) (aa323-464) - LS-G14579

Source:

E. coli

Tag:

His

Molecular Weight:

17.6 kDa

Price:

10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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PKN2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115427

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

111.9 kDa

Price:

100 µg/$710

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Human PKN2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78173

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

111.9 kDa

Price:

20 µg/$215

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