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OTC
ornithine carbamoyltransferase
This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.
| Gene Name: | ornithine carbamoyltransferase |
| Synonyms: | OTC, OCTD, Ornithine carbamoyltransferase, Ornithine transcarbamylase, OTCase |
| Target Sequences: | NM_000531 NP_000522.3 P00480 |
Publications (3)
1
Shotgun proteomics analysis of hibernating arctic ground squirrels. Shao C, Liu Y, Ruan H, Li Y, Wang H, Kohl F, Goropashnaya AV, Fedorov VB, Zeng R, Barnes BM, Yan J. Molecular & cellular proteomics : MCP. 2010 9:313-26. (WB; Ground squirrel)
[Full Text Article]
[PubMed:19955082]
[PMC:PMC2830842]
Related Antibodies: LS-C31865.
2
Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS. Michael Sloth Trabjerg, Dennis Christian Andersen, Pam Huntjens, Kirsten Egelund Oklinski, Luise Bolther, Jonas Laugård Hald, Amalie Elton Baisgaard, Kasper Mørk, Nikolaj Warming, Ulla Bismark Kullab, Lona John Kroese, Colin Eliot Jason Pritchard, Ivo Johan Huijbers, John Dirk Vestergaard Nieland. Communications biology. 2021 April;4:509. [Full Text Article]
[PubMed:33931719]
[PMC:PMC8087699]
3
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures. Joo Sang Lee, Lital Adler, Hiren Karathia, Narin Carmel, Shiran Rabinovich, Noam Auslander, Rom Keshet, Noa Stettner, Alon Silberman, Lilach Agemy, Daniel Helbling, Raya Eilam, Qin Sun, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Hila Weiss, Sivan Pinto, Shelly Kalaora, Ronen Levy, Eilon Barnea, Arie Admon, David Dimmock, Noam Stern-Ginossar, Avigdor Scherz, Sandesh C S Nagamani, Miguel Unda, David M Wilson rd, Ronit Elhasid, Arkaitz Carracedo, Yardena Samuels, Sridhar Hannenhalli, Eytan Ru. Cell. 2018 September;174:1559-1570.e22. [Full Text Article]
[PubMed:30100185]
[PMC:PMC6225773]
Related Antibodies: LS-C31865.
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OTC Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
Sandwich
96-Well Strip Plate
Human
3.12 - 200 U/l
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
E. coli
His
38.9 kDa
50 µg/$411; 250 µg/$985; 10 µg/$276; 20 µg/$332; 100 µg/$544; 500 µg/$1,473
Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
OTC Rabbit anti-Human Polyclonal (aa78-342) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
E. coli
His-SUMO
52.1 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
OTC Mouse anti-Human Monoclonal (aa33-354) (OTI7B1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
OTC Mouse anti-Human Monoclonal (aa33-354) (Carrier-free) (OTI5A7) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
OTC Mouse anti-Human Monoclonal (aa33-354) (OTI3A5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
OTC Mouse anti-Human Monoclonal (aa33-354) (OTI4G4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
OTC Mouse anti-Human Monoclonal (aa33-354) (OTI5F4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
OTC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
OTC Mouse anti-Human Monoclonal (aa33-354) (OTI2C2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
OTC Rabbit anti-Human Polyclonal (aa71-98) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Microplate
Human
0.469 - 30 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Competitive EIA
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
OTC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
OTC Rabbit anti-Human Polyclonal (aa71-98) Antibody
Human
Flo, IHC, WB
Unconjugated
200 µl/$734
OTC Rabbit anti-Human Polyclonal (aa71-98) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
OTC Rabbit anti-Human Polyclonal (aa71-98) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
OTC Rabbit anti-Human Polyclonal (aa71-98) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
OTC Rabbit anti-Human Polyclonal (aa71-98) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
OTC Rabbit anti-Human Polyclonal (aa71-98) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
OTC Mouse anti-Human Monoclonal (aa33-354) (OTI1C4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
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