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This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
Gene Name: | oligodendrocyte lineage transcription factor 2 |
Synonyms: | OLIG2, BHLHB1, BHLHe19, OLIGO2, PRKCBP2, RACK17, Olig 2, Oligo 2 |
Target Sequences: | NM_005806 NP_005797.1 Q13516 |
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