LRP2 / Megalin

low density lipoprotein receptor-related protein 2

LRP2 / Megalin, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

☰ Filters

Products

Proteins (2)

Type

Recombinant (2)

Target

LRP2 / Megalin (2)

Publications

No (2)

Tag

6His, N-terminus (2)

Species

Human (2)

Source

E. coli (1)

Yeast (1)

Select

Human LRP2 / Megalin Protein (Recombinant 6His, N-terminus) (aa1186-1389) - LS-G23013

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

24.2 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

Select

Human LRP2 / Megalin Protein (Recombinant 6His, N-terminus) (aa4035-4184) - LS-G25215

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

21.1 kDa

Price:

10 µg/$252; 50 µg/$315; 100 µg/$417; 200 µg/$522; 1 mg/$1,404; 500 µg/$1,034; 5 mg/$2,303; 2 mg/$1,565

Viewing 1-2 of 2 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.