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KRT1 / CK1 / Cytokeratin 1

keratin 1

KRT1 / CK1 / Cytokeratin 1 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Gene Name: keratin 1
Family/Subfamily: Keratin , not assigned-Keratin
Synonyms: KRT1, 67 kDa cytokeratin, CK-1, CK1, Cytokeratin 1, Cytokeratin-1, Epidermolytic hyperkeratosis 1, EHK, EHK1, Hair alpha protein, EPPK, NEPPK, K1, Keratin-1, KRTA, Type-II keratin Kb1, Type II keratin, Keratin 1, KRT1A
Target Sequences: NM_006121 NP_006112.3 P04264

Publications (5)

1
Activated keratinocytes in the epidermis of hypertrophic scars. Machesney M, Tidman N, Waseem A, Kirby L, Leigh I. The American journal of pathology. 1998 152:1133-41. [PubMed:9588880] [PMC:PMC1858601]
2
Characterization and comparison of reconstructed skin models: morphological and immunohistochemical evaluation. Boelsma E, Gibbs S, Faller C, Ponec M. Acta dermato-venereologica. 80:82-8. [PubMed:10877124]
3
A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis. Mller FB, Huber M, Kinaciyan T, Hausser I, Schaffrath C, Krieg T, Hohl D, Korge BP, Arin MJ. Human molecular genetics. 2006 15:1133-41. (ICC) [PubMed:16505000]
4
Modified plastic compression of collagen hydrogels provides an ideal matrix for clinically applicable skin substitutes. Braziulis E, Diezi M, Biedermann T, Pontiggia L, Schmucki M, Hartmann-Fritsch F, Luginbhl J, Schiestl C, Meuli M, Reichmann E. Tissue engineering. Part C, Methods. 2012 18:464-74. (ICC, IHC; Human) [PubMed:22195768]
5
Human amniotic fluid derived cells can competently substitute dermal fibroblasts in a tissue-engineered dermo-epidermal skin analog. Hartmann-Fritsch F, Hosper N, Luginbhl J, Biedermann T, Reichmann E, Meuli M. Pediatric surgery international. 2013 29:61-9. (ICC, IHC; Human) [PubMed:23138462]
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Proteins (6)
Recombinant (6)
KRT1 / CK1 / Cytokeratin 1 (6)
No (6)
6His, N-terminus (1)
GST, N-terminus (1)
His (3)
His-S (1)
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E. coli (5)
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Purified (1)
KRT1 / CK1 / Cytokeratin 1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
69.9 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
KRT1 / CK1 / Cytokeratin 1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
KRT1 / CK1 / Cytokeratin 1 Protein - Recombinant Keratin 1 By SDS-PAGE
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E. coli
His-S
21.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$3,361
KRT1 / CK1 / Cytokeratin 1 Protein - Recombinant Keratin 1 By SDS-PAGE
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E. coli
His
37.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
KRT1 / CK1 / Cytokeratin 1 Protein - Recombinant Keratin 1 By SDS-PAGE
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E. coli
His
13.5 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
KRT1 / CK1 / Cytokeratin 1 Protein
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E. coli
His
15.1 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$3,361
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).