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IL11
interleukin 11
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
| Gene Name: | interleukin 11 |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | IL11, AGIF, Adipogenesis inhibitory factor, IL-11, Interleukin-11, Interleukin 11 |
| Target Sequences: | NM_000641 NP_000632.1 P20809 |
Publications (1)
1
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer10<sup> Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA12<sup> Department of Immunology, Juntendo University Graduate School of Medicine, Tokyo, Japan14<sup> Department of Pathology, Toho University School of Medicine, Tokyo, Japan16<sup> Host Defense Research Center, Toho University School of Medicine, Tokyo, Japan. hiroyasu.nakano@med.toho-u.a. Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda , Masato Ohtsuka , Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, Hiroyasu Nakano. Nature communications. 2021 Apr;12:2281. [Full Text Article]
[PubMed:33863879]
[PMC:PMC8052408]
Related Antibodies: LS-C408373.
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Products
Proteins
(23)
Type
Over-Expression Lysate
(2)
Recombinant
(21)
Target
IL11
(23)
Format
Animal-free
(1)
Publications
No
(23)
Tag
Fc, C-terminus
(2)
GST
(1)
GST, N-terminus
(1)
His, N-Terminal
(2)
His-T7
(2)
Myc-DDK (Flag)
(2)
Species
Human
(15)
Mouse
(7)
Source
293F Cells
(1)
293T Cells
(1)
CHO Cells
(1)
E. coli
(10)
HEK 293 Cells
(3)
Human Cells
(1)
Mammalian Cells
(1)
Pichia pastoris
(1)
Wheat Germ Extract
(2)
Yeast
(1)
Purification
Purified
(12)
Low Endotoxin Level
Low endotoxin level
(12)
Biologically Active
Biologically active
(10)
Animal-free
Animal-free
(1)
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
19.3 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$282; 10 µg/$370
293F Cells
His, N-Terminal
24kDa
10 µg/$283; 50 µg/$457; 200 µg/$912; 1 mg/$2,032; 5 mg/$3,193; 2 mg/$2,219
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
~23 kDa (SDS-PAGE)
5 µg/$296; 25 µg/$478; 1 mg/$3,661
HEK 293 Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 180 amino acid recombinant protein has a predicted molecular mass of approximately 19.3 kD. The DTT-reduced and non reduced proteins migrate at approximately 19.3 kD by SDS-PAGE. The N-terminal amino acid is Valine.
10 µg/$352; 25 µg/$459; 100 µg/$1,093; 500 µg/$2,996
Wheat Germ Extract
GST
47.52 kDa
2 µg/$439
E. coli
His-T7
22.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
HEK 293 Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
~21 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
None
Biologically active
19.1 kDa
10 µg/$388; 100 µg/$1,466; 500 µg/$3,025
E. coli
None
Biologically active
19.1 kDa
10 µg/$388; 100 µg/$1,466; 500 µg/$3,025
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
19.1 kDa
2 µg/$268; 10 µg/$349
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~19 kDa
10 µg/$291; 100 µg/$404; 1 mg/$2,269
Yeast
None
Less than 1.0 EU/µg protein (determined by LAL method).
19kD
10 µg/$321; 50 µg/$534; 500 µg/$1,353; 1 mg/$1,725
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.3kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.3 kDa
10 µg/$288; 50 µg/$436
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~19 kDa
10 µg/$291; 100 µg/$738; 1 mg/$4,951
Pichia pastoris
None
Less than 1.0 EU/µg protein (determined by LAL method).
19 kDa
10 µg/$317; 50 µg/$524
293T Cells
Myc-DDK (Flag)
21.43 kDa
20 µg/$150
E. coli
His-T7
23.0 kDa
10 µg/$283; 50 µg/$457; 100 µg/$732; 200 µg/$912; 1 mg/$2,032; 500 µg/$1,567; 5 mg/$3,193; 2 mg/$2,219
HEK 293 Cells
Myc-DDK (Flag)
21.43 kDa
100 µg/$494
E. coli
His, N-Terminal
27kDa
10 µg/$362; 50 µg/$902; 200 µg/$1,553; 100 µg/$1,325; 1 mg/$2,881; 500 µg/$2,369; 5 mg/$6,301; 2 mg/$3,361
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