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HGF / Hepatocyte Growth Factor

hepatocyte growth factor (hepapoietin A; scatter factor)

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

Gene Name: hepatocyte growth factor (hepapoietin A; scatter factor)
Family/Subfamily: Protease , Serine S1
Synonyms: HGF, DFNB39, Hepatocyte growth factor, Hepatopoeitin-A, Hepapoietin A, Hepatopoietin-A, Scatter factor), SF, F-TCF, HGFB, HPTA, Scatter factor
Target Sequences: X16323 CAA34387.1 P14210

Publications (6)

1
Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-ß in gastric tissue. Ota M, Horiguchi M, Fang V, Shibahara K, Kadota K, Loomis C, Cammer M, Rifkin DB. Cancer research. 2014 74:2642-51. (WB; Human) [Full Text Article] [PubMed:24590056] [PMC:PMC4158836]
2
Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models. Piao Y, Park SY, Henry V, Smith BD, Tiao N, Flynn DL, de Groot JF. Neuro-oncology. 2016 September;18:1230-41. (Human) [Full Text Article] [PubMed:26965451] [PMC:PMC4998992] Related Antibodies: LS-B4657.
3
N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals. Xiuping Huang, Qing Ye, Min Chen, Aimin Li, Wenting Mi, Yuxin Fang, Yekaterina Y Zaytseva, Kathleen L O'Connor, Craig W Vander Kooi, Side Liu, Qing-Bai She. Nature communications. 2019 August;10:3708. [Full Text Article] [PubMed:31420553] [PMC:PMC6697747]
4
Expression of HGF, pMet, and pAkt is related to benefit of radiotherapy after breast-conserving surgery: a long-term follow-up of the SweBCG91-RT randomised trial. Martin Sjöström, Cynthia Veenstra, Erik Holmberg, Per Karlsson, Fredrika Killander, Per Malmström, Emma Niméus, Mårten Fernö, Olle Stål. Molecular oncology. 2020 September; [Full Text Article] [PubMed:32946618] [PMC:PMC7607179] Related Antibodies: LS-B3265.
5
Impaired integrin a5 /ß1 -mediated hepatocyte growth factor release by stellate cells of the aged liver. Friederike Rohn, Claus Kordes, Tobias Buschmann, Doreen Reichert, Marianne Wammers, Gereon Poschmann, Kai Stühler, Amelie S Benk, Fania Geiger, Joachim P Spatz, Dieter Häussinger. Aging cell. 2020 Apr;19:e13131. [Full Text Article] [PubMed:32157808] [PMC:PMC7189994] Related Antibodies: LS-C486534.
6
Expression of hypoxia-inducible factor-1 alpha and hepatocyte growth factor in development of fibrosis in the transplanted kidney. Kellenberger T, Marcussen N, Nyengaard JR, Wogensen L, Jespersen B. Transplant international : official journal of the European Society for Organ Transplantation. Feb;28:180-90. [Full Text Article] [PubMed:25284705] Related Antibodies: LS-B4957.
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HGF / Hepatocyte Growth Factor (51)
Human (15)
Mouse (11)
Rat (11)
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Canine (1)
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12 x 8-Well Microstrips (5)
96-Well Microplate (10)
96-Well Strip Plate (35)
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Cell Culture Supernatants (20)
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HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Microplate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$559
HGF / Hepatocyte Growth Factor ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
46.875 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Dog
1.37 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$949
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$590
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
HGF / Hepatocyte Growth Factor ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.08 - 5 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$627
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Microplate
Rabbit
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Microplate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$585
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Bovine
1.37 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$987
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
1.37 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$871
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
1.37 - 1000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$911
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$565
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.246 - 24 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.819 - 80 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Dog
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$748
HGF / Hepatocyte Growth Factor ELISA Kit
Select
Sandwich
96-Well Microplate
Canine
0.246 - 24 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
Viewing 1-25 of 51 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).