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H2AFX / H2AX

H2A histone family, member X

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Gene Name:	H2A histone family, member X
Synonyms:	H2AFX, H2AX, Histone H2A.x, H2A.X, H2A histone family, member X, H2AX histone
Target Sequences:	NM_002105 NP_002096.1 P16104

Publications (13)

Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis. Xiao R, Sun Y, Ding JH, Lin S, Rose DW, Rosenfeld MG, Fu XD, Li X. Molecular and cellular biology. 2007 27:5393-402. [PubMed:17526736] [PMC:PMC1952092] Related Antibodies: LS-C41114.

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Nature. 2007 447:725-9. [PubMed:17554309] Related Antibodies: LS-C41114.

DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. Mochizuki K, Novatchkova M, Loidl J. Journal of cell science. 2008 121:2148-58. [PubMed:18522989] [PMC:PMC3184542] Related Antibodies: LS-C41114.

Differential roles of telomere attrition in type I and II endometrial carcinogenesis. Akbay EA, Contreras CM, Perera SA, Sullivan JP, Broaddus RR, Schorge JO, Ashfaq R, Saboorian H, Wong KK, Castrillon DH. The American journal of pathology. 2008 173:536-44. [PubMed:18599611] [PMC:PMC2475790] Related Antibodies: LS-C41114.

Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage. Loidl J, Mochizuki K. Molecular biology of the cell. 2009 20:2428-37. [PubMed:19297526] [PMC:PMC2675622] Related Antibodies: LS-C41114.

gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks?. Beels L, Bacher K, De Wolf D, Werbrouck J, Thierens H. Circulation. 2009 120:1903-9. [PubMed:19858412]

Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor. Pastorino F, Loi M, Sapra P, Becherini P, Cilli M, Emionite L, Ribatti D, Greenberger LM, Horak ID, Ponzoni M. Clinical cancer research : an official journal of the American Association for Cancer Research. 2010 16:4809-21. (IHC-Fr; Mouse) [PubMed:20702613]

Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice. Ramirez-Herrick AM, Mullican SE, Sheehan AM, Conneely OM. Blood. 2011 117:2681-90. [PubMed:21205929] [PMC:PMC3062356]

The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability. Li M, Xu X, Liu Y. Molecular and cellular biology. 2011 31:2090-9. [PubMed:21402780] [PMC:PMC3133350]

The nucleolus directly regulates p53 export and degradation. Boyd MT, Vlatkovic N, Rubbi CP. The Journal of cell biology. 2011 194:689-703. [PubMed:21893597] [PMC:PMC3171122]

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. Conomos D, Stutz MD, Hills M, Neumann AA, Bryan TM, Reddel RR, Pickett HA. The Journal of cell biology. 2012 199:893-906. (ICC; Human) [PubMed:23229897] [PMC:PMC3518223]

Ionizing Radiation-Induced -H2AX Activity in Whole Blood Culture and the Risk of Lung Cancer. He Y, Gong Y, Lin J, Chang DW, Gu J, Roth JA, Wu X. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2013 22:443-51. [PubMed:23300022] [PMC:PMC3601549]

MRPL35 Is Up-Regulated in Colorectal Cancer and Regulates Colorectal Cancer Cell Growth and Apoptosis. Litao Zhang, Peifen Lu, Lihong Yan, Lijun Yang, Yutao Wang, Junjun Chen, Jie Dai, Yahui Li, Zhiming Kang, Tao Bai, Yanfeng Xi, Jun Xu, Gongqin Sun, Tao Yang. The American journal of pathology. 2019 May;;189:1105-1120. [Full Text Article] [PubMed:30862482] Related Antibodies: LS-C348689.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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