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GLI / GLI1

GLI family zinc finger 1

Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.

Gene Name: GLI family zinc finger 1
Synonyms: GLI1, Gli-1, GLI family zinc finger 1, Glioma-associated oncogene, Glioma-associated oncogene 1, Oncogene GLI, GLI, Zinc finger protein GLI1
Target Sequences: NM_005269 NP_005260.1 P08151

Publications (6)

1
Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Niemann C, Unden AB, Lyle S, Zouboulis ChC, Toftgrd R, Watt FM. Proceedings of the National Academy of Sciences of the United States of America. 2003 11873-80. [PubMed:12917489] [PMC:PMC304101]
2
Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. Qualtrough D, Buda A, Gaffield W, Williams AC, Paraskeva C. International journal of cancer. Journal international du cancer. 2004 110:831-7. [PubMed:15170664]
3
Hedgehog signaling drives cellular survival in human colon carcinoma cells. Mazumdar T, DeVecchio J, Shi T, Jones J, Agyeman A, Houghton JA. Cancer research. 2011 71:1092-102. (WB; Human) [PubMed:21135115] [PMC:PMC3032813]
4
Expression of hedgehog pathway components in prostate carcinoma microenvironment: shifting the balance towards autocrine signalling. Tzelepi V, Karlou M, Wen S, Hoang A, Logothetis C, Troncoso P, Efstathiou E. Histopathology. 2011 58:1037-47. (IHC; Human) [PubMed:21707705]
5
Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Mazumdar T, Devecchio J, Agyeman A, Shi T, Houghton JA. Cancer research. 2011 71:5904-14. [PubMed:21747117] [PMC:PMC3165104]
6
Hedgehog signaling inhibition by the small molecule smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b. Karlou M, Lu JF, Wu G, Maity S, Tzelepi V, Navone NM, Hoang A, Logothetis CJ, Efstathiou E. The Prostate. 2012 72:1638-47. (IHC; Human) [PubMed:22457212]
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GLI / GLI1 (7)
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GLI / GLI1 ELISA Kit
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Human GLI / GLI1 (Sandwich ELISA) ELISA Kit - LS-F8635
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
GLI / GLI1 ELISA Kit
Select
Mouse GLI / GLI1 (Sandwich ELISA) ELISA Kit - LS-F25559
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
GLI / GLI1 ELISA Kit
Select
Human GLI / GLI1 (Custom) ELISA Kit - LS-F65215
Custom
96-Well Strip Plate
Human
1 Plate/$669
GLI / GLI1 ELISA Kit
Select
Rat GLI / GLI1 (Sandwich ELISA) ELISA Kit - LS-F56451
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
GLI / GLI1 ELISA Kit
Select
Mouse GLI / GLI1 (Custom) ELISA Kit - LS-F65396
Custom
96-Well Strip Plate
Mouse
1 Plate/$669
GLI / GLI1 ELISA Kit
Select
Rat GLI / GLI1 (Sandwich ELISA) ELISA Kit - LS-F55797
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$783
GLI / GLI1 ELISA Kit
Select
Chicken GLI / GLI1 (Custom) ELISA Kit - LS-F66239
Custom
96-Well Strip Plate
Chicken
1 Plate/$783
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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