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FASLG / Fas Ligand

Fas ligand (TNF superfamily, member 6)

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.

Gene Name: Fas ligand (TNF superfamily, member 6)
Family/Subfamily: TNF , not assigned-TNF
Synonyms: FASLG, ALPS1B, Apoptosis antigen ligand, APTL, CD95L, CD95 ligand, CD178 antigen, CD95-L, Fas antigen ligand, Fas ligand, FASL, TNFSF6, APT1LG1, CD178
Target Sequences: NM_000639 NP_000630.1 P48023

Publications (9)

1
Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis. Strauss L, Bergmann C, Whiteside TL. Journal of immunology (Baltimore, Md. : 1950). 2009 182:1469-80. [PubMed:19155494] Related Antibodies: LS-C40984.
2
Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells. Li JH, D'Alessio A, Pober JS. The American journal of pathology. 2009 175:1124-35. [PubMed:19661440] [PMC:PMC2731131] Related Antibodies: LS-C40984.
3
Intensive resistance exercise induces lymphocyte apoptosis via cortisol and glucocorticoid receptor-dependent pathways. Krger K, Agnischock S, Lechtermann A, Tiwari S, Mishra M, Pilat C, Wagner A, Tweddell C, Gramlich I, Mooren FC. Journal of applied physiology (Bethesda, Md. : 1985). 2011 110:1226-32. [PubMed:21393471] Related Antibodies: LS-C40984.
4
Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection. Khalid M, Yu H, Sauter D, Usmani SM, Schmokel J, Feldman J, Gruters RA, van der Ende ME, Geyer M, Rowland-Jones S, Osterhaus AD, Kirchhoff F. Journal of virology. 2012 86:4906-20. [PubMed:22345473] [PMC:PMC3347365] Related Antibodies: LS-C40984.
5
Phenotypic and functional characterization of human T-cell subsets in response to influenza A viruses. Qin G, Liu Y, Zheng J, Xiang Z, Ng IH, Malik Peiris JS, Lau YL, Tu W. The Journal of infectious diseases. 2012 205:1646-53. [PubMed:22457284] Related Antibodies: LS-C40984.
6
CD8+ T cells use TRAIL to restrict West Nile virus pathogenesis by controlling infection in neurons. Shrestha B, Pinto AK, Green S, Bosch I, Diamond MS. Journal of virology. 2012 86:8937-48. [PubMed:22740407] [PMC:PMC3416144] Related Antibodies: LS-C40984.
7
Exercise delays neutrophil apoptosis by a G-CSF-dependent mechanism. Mooren FC, Vlker K, Klocke R, Nikol S, Waltenberger J, Krger K. Journal of applied physiology (Bethesda, Md. : 1985). 2012 113:1082-90. [PubMed:22858628] Related Antibodies: LS-C40984.
8
IL-1ß Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene. Thiyagarajan D, Pedersen HL, Seredkina N, Horvei KD, Arranz L, Sonneveld R, Nijenhuis T, van der Vlag J, Rekvig OP. Frontiers in cell and developmental biology. 2018 February;6:7. (Human) [Full Text Article] [PubMed:29468159] [PMC:PMC5807897] Related Antibodies: LS-C176019.
9
Pre-treatment With Ranibizumab Aggravates PDT Injury and Alleviates Inflammatory Response in Choroid-Retinal Endothelial Cells. Yang Liu, Min Zhu, Ruowen Gong, Xin Wang, Lei Li, Gezhi Xu. Frontiers in cell and developmental biology. 2020 August;8:608. [Full Text Article] [PubMed:32733897] [PMC:PMC7363772]
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☰ Filters
Products
Proteins (20)
Over-Expression Lysate (2)
Recombinant (18)
FASLG / Fas Ligand (20)
No (20)
6His, N-terminus (1)
DDK (Flag) (1)
DDK (Flag)-Human ACRP30headless aa 18-111 (1)
GST (1)
GST, N-terminus (1)
His (5)
His, N-Terminal (2)
His-GST (2)
His-S (1)
His-T7 (1)
Human IgG1 Fc (1)
Myc-DDK (Flag) (2)
Human (16)
Mouse (1)
Rat (1)
Rhesus monkey (1)
293T Cells (1)
CHO Cells (2)
E. coli (8)
HEK 293 Cells (4)
Human (1)
Wheat Germ Extract (2)
Yeast (2)
Purified (4)
Low endotoxin level (6)
Biologically active (2)
Select
CHO Cells
His, N-Terminal
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.9 kDa
2 µg/$268; 10 µg/$349
Select
HEK 293 Cells
DDK (Flag)
Less than 0.05 EU/µg protein (determined by LAL method).
~33kDa (SDS-PAGE)
10 µg/$323
Select
E. coli
His, N-Terminal
21.7 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
FASLG / Fas Ligand Protein - Recombinant Human Fas Ligand / TNFSF6 (N-6His)
Select
Human
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
17.7 kDa
10 µg/$377; 50 µg/$818
Select
E. coli
His
21.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
E. coli
His
24.5 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
Yeast
His
19.3 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
Select
Yeast
His
22.4 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
FASLG / Fas Ligand Protein - 12.5% SDS-PAGE of human FASLG stained with Coomassie Blue
Select
Wheat Germ Extract
GST
56.65 kDa
10 µg/$479; 25 µg/$670
FASLG / Fas Ligand Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
FASLG / Fas Ligand Protein - Oligomerization of FasL (h) efficiently triggers Jurkat cell death.Method: Jurkat cells were treated O/N with the indicated concentrations of MegaFasL, Soluble (human) (rec.) (rec.) (rec.) or FasL, Soluble (human) (rec.) + TNF ligands enhancer (2 fold-dilutions, first concentration of 1000ng/ml). Cell death was quantified using PMS/MTS. The oligomeric FasL recombinant proteins (MegaFasL, Soluble (human), Fc:FasL, Soluble (human) and FasL, Soluble (human) + TNF ligands enhancer) kill Jurkat cells at IC50 <0.2ng/ml.
Select
HEK 293 Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
~50kDa (SDS-PAGE)
10 µg/$407
FASLG / Fas Ligand Protein - Oligomerization of FasL (h) efficiently triggers Jurkat cell death.Method: Jurkat cells were treated O/N with the indicated concentrations of FasL (human) (multimeric) (rec.) (rec.) (rec.) or FasL, Soluble (human) (rec.) + TNF ligands enhancer (2 fold-dilutions, first concentration of 1000ng/ml). Cell death was quantified using PMS/MTS. The oligomeric FasL recombinant proteins (FasL (human) (multimeric) (rec.), Fc:FasL, Soluble (human) and FasL, Soluble (human) + TNF ligands enhancer) kill Jurkat cells at IC50 <0.2ng/ml.
Select
HEK 293 Cells
DDK (Flag)-Human ACRP30headless aa 18-111
Less than 0.02 EU/µg protein (determined by LAL method).
~40kDa (SDS-PAGE)
10 µg/$435
FASLG / Fas Ligand Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
FASLG / Fas Ligand Protein - Apoptotic cell death induced by human FASL in Jurkat cells.
Select
CHO Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 157 amino acid recombinant protein has a predicted molecular mass of approximately 18 kD. The DTT-reduced and non-reduced protein migrate at approximately 29 to 30 kD by SDS-PAGE. The N-terminal amino acid is Met.
10 µg/$344; 25 µg/$451; 100 µg/$993
FASLG / Fas Ligand Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
31.3 kDa
100 µg/$494
FASLG / Fas Ligand Protein - Recombinant Factor Related Apoptosis Ligand By SDS-PAGE
Select
E. coli
His-GST
52.4 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
FASLG / Fas Ligand Protein - Recombinant Factor Related Apoptosis Ligand By SDS-PAGE
Select
E. coli
His-S
14.3 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
FASLG / Fas Ligand Protein - Recombinant Factor Related Apoptosis Ligand By SDS-PAGE
Select
E. coli
His-GST
52.2 kDa
10 µg/$283; 50 µg/$457; 100 µg/$732; 200 µg/$912; 1 mg/$2,032; 500 µg/$1,567; 5 mg/$3,193; 2 mg/$2,219
FASLG / Fas Ligand Protein - Recombinant Factor Related Apoptosis Ligand By SDS-PAGE
Select
E. coli
His-T7
49.3 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
FASLG / Fas Ligand Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
31.3 kDa
20 µg/$150
Viewing 1-20 of 20 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).