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F8 / FVIII / Factor VIII

coagulation factor VIII, procoagulant component

F8 / FVIII / Factor VIII is coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Gene Name: coagulation factor VIII, procoagulant component
Synonyms: F8, AHF, Antihemophilic factor, Coagulation factor VIIIc, Coagulation factor VIII, DXS1253E, Factor VIII F8B, FVIII, HEMA, F8B, Factor VIII, Procoagulant component, F8C
Target Sequences: NM_000132 NP_000123.1 P00451

Publications (1)

1
Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis. Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis. Clinical and translational gastroenterology. 2020 February;11:e00123. [Full Text Article] [PubMed:32032127] [PMC:PMC7145026]

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Products
Antibodies (120)
Primary (120)
F8 / FVIII / Factor VIII (120)
Human (101)
Mouse (15)
Rat (1)
Bovine (3)
Dog (11)
Monkey (3)
Pig (8)
Rabbit (3)
Sheep (3)
IHC (7)
IHC-P (4)
WB (81)
ELISA (58)
IE (2)
IF (2)
IP (1)
Peptide-ELISA (2)
RIA (2)
rabbit (68)
mouse (40)
rat (1)
sheep (11)
Product Group
IHCPlus (2)
PathPlus Cancer (1)
IgG (28)
IgG1 (18)
IgG1,k (5)
IgG2a (16)
IgG2b,k (1)
monoclonal mc (44)
polyclonal pc (76)
10101 (1)
14E8-F7 (1)
15D9-F9A11 (1)
1C2-G10F10 (1)
1E8 (1)
226 (1)
402 (1)
5E9B2 (2)
8EB (1)
9035 (1)
9C8-E10D8 (2)
F8 2.2.9 (1)
F8 5.5.72 (1)
F8C 27.4 (1)
F8C 27.4 (2A5) (1)
MH104 (1)
RFF-VIIIC/10 (1)
RFF-VIIIC/8 (1)
APC (5)
APC Conjugated (8)
Biotin Conjugated (12)
Cy3 Conjugated (5)
Cy7 Conjugated (5)
FITC Conjugated (12)
HRP Conjugated (15)
PE Conjugated (9)
Preservative Free (2)
Unconjugated (54)
aa1669-1824 (8)
aa1854-1989 (8)
aa1887-2044 (8)
aa2191-2337 (8)
aa2253-2346 (8)
aa1790-1839 (4)
2130-2210 aa, C-terminal (1)
C-Terminus (1)
Ser2194 (1)
aa1264-1278 (1)
aa2161-2210 (1)
aa2187-2209 (1)
No (120)
F8 / FVIII / Factor VIII Antibody - Anti-F8 / Factor VIII antibody IHC of human placenta, vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Cancer
F8 / FVIII / Factor VIII Mouse anti-Human Monoclonal (F8 2.2.9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$495
F8 / FVIII / Factor VIII Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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F8 / FVIII / Factor VIII Rabbit anti-Pig Polyclonal (aa1669-1824) Antibody
Pig
IHC, IHC-P, WB
Unconjugated
100 µl/$460
F8 / FVIII / Factor VIII Antibody - Anti-F8 / Factor VIII antibody IHC of human skeletal muscle and capillaries. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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F8 / FVIII / Factor VIII Sheep anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
0.5 mg/$440
F8 / FVIII / Factor VIII Antibody - Factor VIII staining in C57 cells. Formalin-fixed mouse C57 cells are stained with Factor VIII Antibody used at 1:200 dilution and a PE-conjugated secondary antibody.
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F8 / FVIII / Factor VIII Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$432
F8 / FVIII / Factor VIII Antibody - F8 / Factor VIII antibody Western blot of 721_B cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (aa1790-1839) Antibody
Human
WB
Unconjugated
100 µl/$424
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F8 / FVIII / Factor VIII Sheep anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IE
HRP Conjugated
200 µg/$657
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F8 / FVIII / Factor VIII Sheep anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IE
HRP Conjugated
200 µg/$765
F8 / FVIII / Factor VIII Antibody - Western blot of. Factor VIII (S2194) pAb in extracts from HUVEC cells.
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F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (Ser2194) Antibody
Mouse, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
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F8 / FVIII / Factor VIII Sheep anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
100 µg/$850
F8 / FVIII / Factor VIII Antibody - Western blot of recombinant F8 / FVIII / Factor VIII.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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F8 / FVIII / Factor VIII Rabbit anti-Pig Polyclonal (aa1669-1824) (Biotin) Antibody
Pig
WB
Biotin Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$563; 1 ml/$678; 2 ml/$915; 5 ml/$1,541
F8 / FVIII / Factor VIII Antibody - 1:100 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (aa2187-2209) Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
F8 / FVIII / Factor VIII Antibody - Western blot analysis of Factor VIII expression in HeLa (A); HepG2 (B) whole cell lysates.
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F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Human
WB
Unconjugated
100 µl/$299
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F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$937
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F8 / FVIII / Factor VIII Rabbit anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
F8 / FVIII / Factor VIII Antibody - Western blot of recombinant F8 / FVIII / Factor VIII.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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F8 / FVIII / Factor VIII Rabbit anti-Mouse Polyclonal (aa1854-1989) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
F8 / FVIII / Factor VIII Antibody - Western blot of recombinant F8 / FVIII / Factor VIII.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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F8 / FVIII / Factor VIII Rabbit anti-Mouse Polyclonal (aa1854-1989) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
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F8 / FVIII / Factor VIII Mouse anti-Human Monoclonal (F8C 27.4 (2A5)) Antibody
Human
ELISA
Unconjugated
0.2 mg/$486
F8 / FVIII / Factor VIII Antibody - Western blot of Factor VIII antibody
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F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (2130-2210 aa, C-terminal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
F8 / FVIII / Factor VIII Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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F8 / FVIII / Factor VIII Rat anti-Mouse Monoclonal (9035) Antibody
Mouse
ELISA, IHC-P, WB
Unconjugated
100 µg/$428; 500 µg/$665
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F8 / FVIII / Factor VIII Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$860
F8 / FVIII / Factor VIII Antibody - Western blot using F8 mouse monoclonal antibody against truncated Trx-F8 recombinant protein (1).
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F8 / FVIII / Factor VIII Mouse anti-Human Monoclonal (5E9B2) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$435
F8 / FVIII / Factor VIII Antibody - Western blot of recombinant F8 / FVIII / Factor VIII.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (aa2253-2346) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
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F8 / FVIII / Factor VIII Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
100 µl/$951
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F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
F8 / FVIII / Factor VIII Antibody - Western blot of recombinant F8 / FVIII / Factor VIII.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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F8 / FVIII / Factor VIII Rabbit anti-Human Polyclonal (aa1887-2044) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).