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CYBB / NOX2 / gp91phox
cytochrome b-245, beta polypeptide
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
| Gene Name: | cytochrome b-245, beta polypeptide |
| Synonyms: | CYBB, Chronic granulomatous disease, CGD91-phox, Cytochrome b558 subunit beta, Cytochrome b(558) subunit beta, gp91-1, gp91-PHOX, p22 phagocyte B-cytochrome, AMCBX2, CGD, Cytochrome b-245 heavy chain, gp91PHOX, NADPH oxidase 2, NOX2, p91-PHOX |
| Target Sequences: | NM_000397 NP_000388.2 P04839 |
Publications (10)
1
Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways. Trocme C, Deffert C, Cachat J, Donati Y, Tissot C, Papacatzis S, Braunersreuther V, Pache JC, Krause KH, Holmdahl R, Barazzone-Argiroffo C, Carnesecchi S. The Journal of pathology. 2015 235:65-78. (WB; Human)
[Full Text Article]
[PubMed:25116588]
[PMC:PMC4280678]
2
NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy. Brandt M, Garlapati V, Oelze M, Sotiriou E, Knorr M, Kröller-Schön S, Kossmann S, Schönfelder T, Morawietz H, Schulz E, Schultheiss HP, Daiber A, Münzel T, Wenzel P. Scientific reports. 2016 6:32554. (IHC; Human)
[Full Text Article]
[PubMed:27624556]
[PMC:PMC5021994]
3
Decreased NOX2 expression in the brain of patients with bipolar disorder: association with valproic acid prescription and substance abuse. Seredenina T, Sorce S, Herrmann FR, Ma Mulone XJ, Plastre O, Aguzzi A, Jaquet V, Krause KH. Translational psychiatry. 2017 August;7:e1206. [Full Text Article]
[PubMed:28809856]
[PMC:PMC5611741]
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CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal (aa471-510) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CYBB / NOX2 / gp91phox Mouse anti-Human Monoclonal (7D5) Antibody
Human
Flo
Unconjugated
100 µg/$430
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal (aa442-459) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CYBB / NOX2 / gp91phox Mouse anti-Human Monoclonal (FITC) (7D5) Antibody
Human
Flo
FITC Conjugated
100 µl/$464
CYBB / NOX2 / gp91phox Mouse anti-Human Monoclonal (PE) (7D5) Antibody
Human
Flo
PE Conjugated
50 Tests/$451
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal (aa512-561) (FITC) Antibody
Rabbit, Bat, Gibbon, Human, Chimpanzee
WB
FITC Conjugated
100 µl/$469
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Sheep, Rat, Pig, Human
WB
Unconjugated
100 µl/$299
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$893
E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
E. coli
His, N-Terminal
36.9 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Competitive EIA
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CYBB / NOX2 / gp91phox Goat anti-Human Polyclonal (aa151-163) Antibody
Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal (aa548-560) Antibody
Mouse, Rat, Bat, Human, Monkey
WB
Unconjugated
200 µg/$947
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal (aa283-570) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
CYBB / NOX2 / gp91phox Mouse anti-Human Monoclonal (54.1) Antibody
Human
ICC, IF, IHC-P, WB
Unconjugated
0.1 mg/$482
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Fast Shipping
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CYBB / NOX2 / gp91phox Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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