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Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Gene Name: | cadherin-related 23 |
Family/Subfamily: | Cadherin , not assigned-Cadherin |
Synonyms: | CDH23, Bus, Cadherin 23, Cadherin related 23, Cadherin-like 23, Cadherin-related 23, CDHR23, Bustling, DFNB12, Otocadherin, USH1D, Waltzer, Cadherin-23, KIAA1774, KIAA1812, Usher syndrome 1D |
Target Sequences: | NM_022124 NP_071407.4 Q9H251 |
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