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CASP9 / Caspase 9

caspase 9, apoptosis-related cysteine peptidase

CASP9 / Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Gene Name: caspase 9, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP9, APAF3, CASPASE-9c, ICE-LAP6, MCH6, ICE-like apoptotic protease 6, APAF-3, Apoptotic protease Mch-6, CASP-9, Caspase 9, Caspase-9, PPP1R56
Target Sequences: NM_001229 NP_001220.2 P55211

Publications (2)

1
Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis. Martin AG, Fearnhead HO. The Journal of biological chemistry. 2002 277:50834-41. [PubMed:12393884]
2
Caspase-9 acts as a regulator of necroptotic cell death10<sup> Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Hungary. Tamás Molnár , Petra Pallagi , Bálint Tél , Róbert Király, Eszter Csoma, Viktória Jenei, Zsófia Varga , Péter Gogolák, Anne Odile Hueber, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Aladár Pettkó-Szandtner, Attila Bácsi, László Virág, József Maléth , Gábor Koncz. The Breast : official journal of the European Society of Mastology. 2021 Nov;;288:6476-6491. [Full Text Article] [PubMed:33899329] Related Antibodies: LS-C148248.

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ELISA Kits (31)
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CASP9 / Caspase 9 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$715
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Microplate
Rat
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$782
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$764
CASP9 / Caspase 9 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CASP9 / Caspase 9 ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$585
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CASP9 / Caspase 9 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CASP9 / Caspase 9 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CASP9 / Caspase 9 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CASP9 / Caspase 9 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Microplate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CASP9 / Caspase 9 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CASP9 / Caspase 9 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CASP9 / Caspase 9 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$822
CASP9 / Caspase 9 ELISA Kit
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Sandwich
96-Well Strip Plate
Canine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).