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Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.
Gene Name: | Apelin |
Synonyms: | APLN, AGTRL1 ligand, Apelin, APEL, Preproapelin, APJ endogenous ligand, XNPEP2 |
Target Sequences: | NM_017413 NP_059109.3 Q9ULZ1 |
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