Lysophosphatidic acid receptor 4 (LPAR4) is a mediator of diverse cellular activities. It transduces signals by increasing intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA. LPAR4 has highest membranous positivity in the hippocampus, corpus callosum, thalamus and amygdala in the brain, and it is also found throughout the central nervous system, on granulocytes, in the ovaries, and at low levels in various tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804