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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16276-100 | 100 µg (200 µg/ml) | $525 |
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PathPlus™ Recombinant Monoclonal Rabbit anti‑Human DES / Desmin Antibody (clone DES/2960R, IHC) LS‑B16276
PathPlus™ Recombinant Monoclonal Rabbit anti‑Human DES / Desmin Antibody (clone DES/2960R, IHC) LS‑B16276
Note: This antibody replaces LS-C751117
Antibody:
DES / Desmin Rabbit anti-Human Recombinant Monoclonal (DES/2960R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
DES / Desmin Rabbit anti-Human Recombinant Monoclonal (DES/2960R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
Desmin (DES) is a subunit of intermediate filaments in muscles that controls sarcomere architecture. Mutations in desmin that result in excess aggregation of the protein throughout the cell are associated with cardiomyopathy and myofibrillar myopathy diseases. In immunohistochemistry, desmin is commonly used as a mesenchymal marker and is useful for confirming myogenic origin of tissues and distinguishing smooth muscle tumors (desmin positive) from GIST (desmin negative). It is also positive in reactive mesothelial cells, skeletal muscle tumors, leiomyomas and rhabdomyosarcomas.
References: Biophysical Reviews. 2018 Aug. 10 (4): 983–1006, PMID: 29926427; Biochimica et Biophysica Acta. 2014 Feb. 1838 (2): 700–22, PMID: 23860255; Journal of Structural Biology. 2014 Nov. 148 (2): 137–52, PMID: 15477095; The American Journal of Cardiology. 2013 Feb. 111 (3): 400–5, PMID: 23168288; Genet Med. 2019 May;21(5):1246-1247, PMID: 30262925
Target
Human DES / Desmin
Synonyms
DES | ARVC7 | ARVD7 | CMD1I | CSM1 | CSM2 | MFM1 | SCPNK | Desmin | Intermediate filament protein
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Recombinant Monoclonal
Clone
DES/2960R
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified.
Also available Azide-free, Carrier-free.
Immunogen
Recombinant full-length human DES protein. Antigen Molecular Weight: 52 kDa
Specificity
Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.
Applications
- IHC - Paraffin (1:100)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistology (Formalin-fixed - 1-2 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
About DES / Desmin
Validation
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ DES / Desmin Antibody (clone DES/2960R) for IHC LS-B16276 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot
Species:
Human, Mouse, Rat, Pig, Rabbit, Chicken
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Mouse, Rat, Dog, Goat, Hamster, Chicken
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot
Species:
Human, Mouse, Rat, Dog, Hamster, Pig, Rabbit
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 5/5/2024
Date Requested: 5/5/2024
