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| Catalog Number | Size | Price |
|---|---|---|
| LS-B6881-0.1 | 0.1 ml (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human CANX / Calnexin Antibody (aa500‑C‑term, IHC, IF, WB) LS‑B6881
PathPlus™ Polyclonal Rabbit anti‑Human CANX / Calnexin Antibody (aa500‑C‑term, IHC, IF, WB) LS‑B6881
Note: This antibody replaces LS-C142768, LS-C77591
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Specifications
Description
CANX (also called calnexin) is a calcium-binding molecular chaperone protein that is involved in facilitating the assembly and folding of newly synthesized N-linked glycoproteins. It is a stress-induced protein located in the endoplasmic reticulum membrane. It is also found in melanosomes, where it appears to be involved in melanosome biogenesis. CANX is broadly expressed in normal and diseased tissues, and expression may be increased or decreased in certain types of cancers.
References: EMBO J. 2012;31(7):1823-1835. doi: 10.1038/emboj.2012.15; J Proteome Res. 2003;2(1):69-79. PMID: 12643545; J Transl Med. 2016;14(1):196. doi: 10.1186/s12967-016-0948-z; Cancer Lett. 2004;203(2):225-231. PMID: 14732231; Lung Cancer. 2015;90(2):342-345. doi: 10.1016/j.lungcan.2015.08.015; J Cell Mol Med. 2017;21(12):3141-3149. doi: 10.1111/jcmm.13413.
Target
Human CANX / Calnexin
Synonyms
CANX | CNX | Calnexin | IP90 | p90
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
A synthetic peptide corresponding to residues near the C-Terminus of human Calnexin was used as an immunogen.
Epitope
aa500-C-term
Applications
- IHC
- IHC - Paraffin (5 µg/ml)
- ICC
- Immunofluorescence
- Western blot (1:2000)
- Immunoprecipitation (1:100)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Sequence has 100% homology with mouse, Xenopus laevis, dog, hamster, orangutan, rat, cow, chicken, Drosophilia melanogaster, guinea pig, quail, pig, rabbit, and sheep.
Presentation
PBS, 0.05% Sodium Azide, 30% Glycerol
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CANX / Calnexin
Validation
Anti-Calnexin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-Calnexin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
See More About...
LSBio Ratings
PathPlus™ CANX / Calnexin Antibody (aa500-C-term) for IHC, ICC, IF/Immunofluorescence, WB/Western, IP LS-B6881 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (2)
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. Luis V Nobre, Katie Nightingale, Benjamin J Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A Davies, Sepehr Seirafian, Eddie Cy Wang, Andrew J Davison, Gavin Wg Wilkinson, Richard J Stanton, Edward L Huttlin, Michael P Weekes. eLife. 2019 Dec;8:e49894.
Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection. Jonas D Albarnaz , Joanne Kite , Marisa Oliveira , Hanqi Li, Ying Di, Maria H Christensen, Joao A Paulo, Robin Antrobus, Steven P Gygi, Florian I Schmidt, Edward L Huttlin, Geoffrey L Smith, Michael P Weekes. Nature communications. 2023 December;14:8134.
Customer Reviews (0)
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Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/10/2024
Date Requested: 11/10/2024
