The Immunohistochemistry Antibody Company
|Human, Mouse, Rat, Primate (tested or 100% immunogen sequence identity)|
|WNK4 antibody was raised against kLH-conjugated synthetic peptide from the C-term region of human PRKWNK4.|
|The applications listed have been tested for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.|
|PBS, pH 7.2, 0.09% sodium azide.|
|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months.|
|For research use only.|
WNK4 Antibody, PHA2B Antibody, PRKWNK4 AntibodySerine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3.