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PSEN1 / Presenilin 1
presenilin 1
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
| Gene Name: | presenilin 1 |
| Family/Subfamily: | protease , Aspartic A22A |
| Synonyms: | PSEN1, AD3, Alzheimer disease 3, FAD, Protein S182, PS1, S182, PS-1, PSNL1, Presenilin 1, Presenilin-1 |
| Target Sequences: | NM_000021 NP_000012.1 P49768 |
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PSEN1 / Presenilin 1
(100)
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(77)
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(1)
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal Antibody
Xenopus, Rat, Mouse, Human
ELISA, WB
Unconjugated
100 µg/$832
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (aa107-156) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
E. coli
6His, N-terminus
22.2 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (aa300-349) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (aa1-160) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
PSEN1 / Presenilin 1 Rat anti-Human Monoclonal (N-Terminus) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µl/$786
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/nl
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$893
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (aa323-372) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (pSer357) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PSEN1 / Presenilin 1 Mouse anti-Human Monoclonal (aa313-334) Antibody
Human
ELISA, ICC, WB
Unconjugated
200 µg/$1,032
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (aa330-359) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (aa330-359) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (aa330-359) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (300-380 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (300-380 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (pSer357) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
PSEN1 / Presenilin 1 Rabbit anti-Human Polyclonal (aa275-367) Antibody
Mouse, Hamster, Human, Monkey
ICC, IP, WB
Unconjugated
100 µl/$907
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