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LAG3
lymphocyte-activation gene 3
Lymphocyte-Activation Protein 3 (LAG3) belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.
| Gene Name: | lymphocyte-activation gene 3 |
| Synonyms: | LAG3, CD223 antigen, LAG-3, Protein FDC, CD223, FDC, Lymphocyte-activation gene 3 |
| Target Sequences: | NM_002286 P18627 P18627 |
Publications (15)
1
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, Blosser RL, Fan H, Wang H, Luber BS, Zhang M, Papadopoulos N, Kinzler KW, Vogelstein B, Sears CL, Anders RA, Pardoll DM, Housseau F. Cancer discovery. 2015 5:43-51. (ELISA; Human)
[Full Text Article]
[PubMed:25358689]
[PMC:PMC4293246]
2
LAG3 expression in active Mycobacterium tuberculosis infections. Phillips BL, Mehra S, Ahsan MH, Selman M, Khader SA, Kaushal D. The American journal of pathology. 2015 185:820-33. (IHC; Macaque)
[Full Text Article]
[PubMed:25549835]
[PMC:PMC4348466]
3
Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade. Taube JM, Young GD, McMiller TL, Chen S, Salas JT, Pritchard TS, Xu H, Meeker AK, Fan J, Cheadle C, Berger AE, Pardoll DM, Topalian SL. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 21:3969-76. (IHC; Human)
[Full Text Article]
[PubMed:25944800]
[PMC:PMC4558237]
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(108)
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(30)
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(9)
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(1)
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(108)
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(26)
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(8)
Target
LAG3
(147)
Reactivity
Human
(83)
Mouse
(26)
Rat
(12)
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(3)
Drosophila
(3)
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(3)
Application
IHC
(23)
IHC-Fr
(12)
IHC-P
(15)
WB
(85)
Flo
(35)
ELISA
(24)
Func
(11)
ICC
(19)
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(8)
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(2)
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(13)
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(1)
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(1)
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rabbit
(58)
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(38)
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(3)
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(9)
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(4)
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(1)
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(1)
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(28)
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(19)
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(7)
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(8)
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(2)
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(11)
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monoclonal mc
(49)
polyclonal pc
(57)
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(1)
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(8)
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(6)
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(1)
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(9)
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(10)
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aa66-332
(10)
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(8)
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(8)
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(8)
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(7)
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(6)
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(4)
aa29-450
(4)
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(1)
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(1)
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(1)
aa23-442
(1)
Publications
No
(144)
Yes
(3)
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(2)
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(2)
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(6)
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(6)
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(5)
Tag
6His, C-terminus
(4)
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(1)
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(1)
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(4)
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(1)
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(1)
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(1)
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(2)
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(3)
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(1)
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(1)
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(1)
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(1)
Myc-DDK (Flag)
(2)
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(2)
Human
(21)
Mouse
(4)
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(2)
Source
293T Cells
(1)
CHO Cells
(2)
E. coli
(5)
HEK 293 Cells
(8)
Human
(2)
Human Cells
(4)
Mammalian Cells
(7)
Wheat Germ Extract
(1)
Purification
Purified
(8)
Low Endotoxin Level
Low endotoxin level
(17)
LAG3 Rabbit anti-Mouse Polyclonal (aa274-504) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
100 µl/$460
LAG3 Goat anti-Human Polyclonal (Extracellular Domain) (PerCP) Antibody
Human
Flo
PerCP Conjugated
100 Tests/$941
LAG3 Rabbit anti-Rat Polyclonal (aa209-451) Antibody
Rat
IHC, IHC-P, WB
Unconjugated
50 µl/$460
LAG3 Mouse anti-Human Monoclonal (11E3) Antibody
Human, Monkey
ELISA, ICC, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$708
LAG3 Mouse anti-Human Monoclonal (N-Terminal) (Preservative Free) (17B4) Antibody
Human
Func, ICC, IHC, IHC-Fr, IP, WB
Unconjugated, Preservative Free
100 µg/$484
LAG3 Mouse anti-Human Monoclonal (aa70-99) (17B4) Antibody
Human
Func, ICC, IHC-Fr, WB
Unconjugated
100 µg/$484
LAG3 Mouse anti-Human Monoclonal (aa70-99) (Biotin) (17B4) Antibody
Human
ELISA, Func, ICC, IHC, IHC-Fr, IP, WB
Biotin Conjugated
100 µg/$484
LAG3 Mouse anti-Human Monoclonal (aa70-99) (FITC) (17B4) Antibody
Human
Flo, Func, ICC, IHC, IHC-Fr, IP, WB
FITC Conjugated
100 µg/$491
LAG3 Mouse anti-Human Monoclonal (aa70-99) (Atto 647N) (17B4) Antibody
Human
Flo, Func, ICC, IHC, IHC-Fr, IP, WB
Atto 647N Conjugated
100 Tests/$498
LAG3 Mouse anti-Human Monoclonal (aa66-332) (OTI8F6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
LAG3 Rabbit anti-Human Polyclonal (aa103-132) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
LAG3 Goat anti-Human Polyclonal (APC) Antibody
Human
Flo
APC Conjugated
100 Tests/$896
Cancer Pathology
Cancer
LAG3 Mouse anti-Human Monoclonal (9F9) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P
Unconjugated
0.05 mg/$460
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
LAG3 Rat anti-Mouse Monoclonal (Low Endotoxin) (C9B7W) Antibody
Mouse
Flo
Unconjugated, Low Endotoxin
0.5 mg/$671
LAG3 Mouse anti-Human Monoclonal (11E3) Antibody
Human, Monkey
ELISA, Func, ICC, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$484
LAG3 Rat anti-Mouse Monoclonal (C9B7W) Antibody
Mouse
Flo, Func
Unconjugated
500 µg/$1,019
LAG3 Mouse anti-Human Monoclonal (aa66-332) (OTI5C3) Antibody
Human
WB
Unconjugated
100 µl/$434
LAG3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
LAG3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
LAG3 Rabbit anti-Mouse Polyclonal (aa274-504) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45.5kD
10 µg/$277; 50 µg/$395; 500 µg/$1,203; 1 mg/$1,627
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
LAG3 Rabbit anti-Human Polyclonal (aa103-132) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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