Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Mouse, Rat, Bovine, Hamster, Zebrafish (tested or 100% immunogen sequence identity)
IHC - Paraffin (3.75 µg/ml), Western blot (0.3 - 2 µg/ml), ELISA (1:32000)
Specificity and Use
HSD17B10 / HADH2 antibody was raised against synthetic peptide C-IRLDGAIRMQP from the C-terminus of human HSD17B10 (NP_004484.1; NP_001032900.1). Percent identity by BLAST analysis: Human, Mouse, Rat, Hamster, Bovine, Lizard, Catfish, Salmon, Stickleback, Zebrafish (100%).
Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids.