Human GJA1 / CX43 / Connexin 43

Rabbit

Human, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig, Sheep, Chicken (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide from the C-Terminus of human Connexin 43 (RASSRASSRPRPDDLEI, aa366-382 of UniProt P17302). Percent identity by BLAST analysis: Human, Mouse, Ferret, Sheep, Cat, Bat, Hamster, Elephant, Horse, Pig, Opossum, Guinea pig, Zebra finch, Chicken, Lizard, Dog (100%).

aa366-382

Human GJA1 / CX43 / Connexin 43

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

Connexin 43 (Cx43), also called GAP Junction Protein, alpha-1 (GJA1), is a member of the connexin gene family which abundantly expressed in the heart and liver and was mapped to 6q21-q23.2. Connexin 43, the major protein of gap junctions in the heart, is targeted by several protein kinases that regulate myocardial cell-cell coupling. Mutations in the gene, which lead to abnormally regulated cell-cell communication, are associated with visceroatrial heterotaxia. Cx43 also plays a critical role in the physiology of hearing, presumably by participating in the recycling of potassium to the cochlear endolymph.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P17302 NCBI: NM_000165 NP_000156.1