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Anti-FANCD2 Antibody (N-Terminus) IHC-plus™ LS-B493

Note: This antibody replaces LS-C2551

Ordering

Wt. Vol. Conc. Price
- 50 µl 1 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular FANCD2 Antibodies

Anti-FANCD2 Antibody (clone 6) IHC-plus™ LS-B196
Mouse Monoclonal [clone 6] (IgG) to Human FANCD2
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-FANCD2 Antibody (N-Terminus) IHC-plus™ LS-B493
Rabbit Polyclonal to Human FANCD2
Human, Mouse, Primate
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (2)
Rabbit Polyclonal to Human FANCD2
Human, Mouse, Primate
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation (applications tested for the base form of this product only)
Unconjugated

Details

Human FANCD2
Rabbit
Human, Mouse, Primate (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated. Also available conjugated with Biotin, DY650, DY488, DY550.
Affinity purified
Unmodified

Applications

  • IHC - Paraffin (2.5 - 5 µg/ml)
  • Immunofluorescence (1:200 - 1:500)
  • Western blot (1:10000 - 1:20000)
  • Immunoprecipitation
  • (applications tested for the base form of this product only)

Specificity and Use

FANCD2 antibody was raised against human FANCD2 fusion protein (N-terminal fragment)
N-Terminus
FANCD2.
Immunohistochemistry: LS-B493 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B493 was determined to be 2.5-5 ug/ml.

Packaging

Tris-glycine, 150 mM NaCl, pH 7.5, 0.05% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

Publications (2)

1
Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance. Tuul M, Kitao H, Iimori M, Matsuoka K, Kiyonari S, Saeki H, Oki E, Morita M, Maehara Y. PloS one. 2013 8:e55361. [Full Text Article] [PubMed:23383325] [PMC:PMC3562228]
2
Significance of the Fanconi anemia FANCD2 protein in sporadic and metastatic human breast cancer. Rudland PS, Platt-Higgins AM, Davies LM, de Silva Rudland S, Wilson JB, Aladwani A, Winstanley JH, Barraclough DL, Barraclough R, West CR, Jones NJ. The American journal of pathology. 2010 Jun;176:2935-47. [Full Text Article] [PubMed:20363922] [PMC:PMC2877854]

About FANCD2

Q9BXW9 NM_033084 NP_149075.2

FANCD2 Antibody, FA-D2 Antibody, FAD Antibody, FACD Antibody, FA4 Antibody, FAD2 Antibody, FANCD Antibody, Protein FACD2 Antibody

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair.

Immunohistochemistry

Immunohistochemistry
Anti-FANCD2 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B493 concentration 2.5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Immunohistochemistry
Anti-FANCD2 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B493 concentration 2.5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Requested From: United States
Date Requested: 12/5/2016

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